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Armin Heckel
Researcher at Boehringer Ingelheim
Publications - 142
Citations - 3856
Armin Heckel is an academic researcher from Boehringer Ingelheim. The author has contributed to research in topics: Cyclin-dependent kinase & Alkyl. The author has an hindex of 22, co-authored 142 publications receiving 3654 citations. Previous affiliations of Armin Heckel include Neurocrine Biosciences.
Papers
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Journal ArticleDOI
The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.
Silke Hauf,Richard W. Cole,Sabrina LaTerra,Christine Zimmer,Gisela Schnapp,Rainer Walter,Armin Heckel,Jacques van Meel,Conly L. Rieder,Jan-Michael Peters +9 more
TL;DR: The data suggest that Aurora B is required to generate unattached kinetochores on monooriented chromosomes, which in turn could promote bipolar attachment as well as maintain checkpoint signaling.
Journal ArticleDOI
BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy
Frank Hilberg,Gerald Juergen Roth,Martin Krššák,Susanna Kautschitsch,Wolfgang Sommergruber,Ulrike Tontsch-Grunt,Pilar Garin-Chesa,Gerd Bader,Andreas Zoephel,Jens Quant,Armin Heckel,Wolfgang Rettig +11 more
TL;DR: Although BIBF 1120 is rapidly metabolized in vivo by methylester cleavage, resulting in a short mean residence time, once daily oral dosing is fully efficacious in xenograft models, preclinical findings suggest that long-term clinical outcomes may improve with blockade of additional proangiogenic receptor tyrosine kinases.
Journal ArticleDOI
Design, Synthesis, and Evaluation of Indolinones as Triple Angiokinase Inhibitors and the Discovery of a Highly Specific 6-Methoxycarbonyl-Substituted Indolinone (BIBF 1120)
Gerald Juergen Roth,Armin Heckel,Florian Colbatzky,Sandra Handschuh,Jörg Kley,Thorsten Lehmann-Lintz,Ralf Lotz,Ulrike Tontsch-Grunt,Rainer Walter,Frank Hilberg +9 more
TL;DR: Preclinical findings suggest that blockade of additional pro-angiogenic kinases, such as fibroblast and platelet-derived growth factor receptors (FGFR and PDGFR), may improve the efficacy of pharmacological cancer treatment.
Journal ArticleDOI
Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction
Jochen H. Weishaupt,Lothar Kussmaul,Philipp Grötsch,Armin Heckel,Gundula Rohde,H Romig,Mathias Bähr,Frank Gillardon +7 more
TL;DR: Testing a new class of CDK inhibitors, it is found that inhibitory activity against CDK5, but not cell cycle-relevant CDKs, confers neuroprotection, and the firstCDK5-selective small molecule inhibitor is presented, lacking unwanted cytostatic effects due to cross-inhibition of mitoticCDKs.
Patent
6-position substituted indoline, production and use thereof as a medicament
Armin Heckel,Gerald Jürgen Roth,Rainer Walter,Jacobus C. A. Van Meel,Norbert Redemann,Ulrike Tontsch-Grunt,Walter Spevak,Frank Hilberg +7 more
TL;DR: In this paper, a 6-substituted indoline of formula (I), wherein R1 to R5 and X are as defined in claim 1, isomers and salts of a compound, in particular physiologically compatible salts of said compound having pharmacologically important characteristics, in addition inhibiting action on different receptor-tyrosine kinases and cyclin/CDK complexes.