Arnaud Charil

TL;DR: The aim of this review is to summarize the existing animal literature by focusing on specific brain regions that have been shown to be affected by PS both macroscopically and microscopically, and to show how it is possible to circumvent challenges by studying the effects of PS on brain development directly in humans by taking advantage of natural or man-made disasters.

TL;DR: The results suggest that the white matter lesions in multiple sclerosis might be associated with aberrant neuronal connectivity among widely distributed brain regions, and provide structural (morphological) evidence for the notion of multiple sclerosis as a disconnection syndrome.

TL;DR: A series of MRI red flags in the setting of clinically suspected multiple sclerosis that is derived from evidence-based findings and educated guesses are defined, which should represent a first step beyond the concept of "no better explanation", and inform future diagnostic criteria for multiple sclerosis.

TL;DR: It is suggested that cortical atrophy occurs even in MS patients with only mild disability, and a specific regional pattern of focal atrophy in MS that is distinctively different from the one in normal aging is shown.

TL;DR: An animal model that allows high-contrast imaging of wild-type glioma cells by positron emission tomography using [18 F]PBR111 using the mitochondrial 18 kDa Translocator Protein (TSPO) combined with the exclusive expression of TSPO makes it possible, for the first time, to unequivocally and with uniquely high biological contrast identify peri-tumoral gliomas cell invasion at preclinical stages in vivo.