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Arpit Mishra
Researcher at University of Washington
Publications - 26
Citations - 477
Arpit Mishra is an academic researcher from University of Washington. The author has contributed to research in topics: Bubble & Cas9. The author has an hindex of 9, co-authored 23 publications receiving 287 citations. Previous affiliations of Arpit Mishra include Indian Institute of Technology Kharagpur & Council of Scientific and Industrial Research.
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Journal ArticleDOI
Candidate silencer elements for the human and mouse genomes
TL;DR: Uncharacterized cis -regulatory elements (CREs) in human and mouse genomes likely containing silencer elements are defined and tested in cells using massively parallel reporter assays to identify silencers elements that showed silencer activity.
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Three-dimensional genome architecture and emerging technologies: looping in disease.
Arpit Mishra,R. David Hawkins +1 more
TL;DR: This review focuses on how recent technological advances in 3D genomics are leading to an enhanced understanding of disease mechanisms and the use of genome-wide chromatin conformation capture coupled with oligonucleotide capture technology to map interactions between gene promoters and distal regulatory elements.
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Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing.
Sundaram Acharya,Sundaram Acharya,Arpit Mishra,Deepanjan Paul,Asgar Hussain Ansari,Asgar Hussain Ansari,Mohd Azhar,Mohd Azhar,Manoj Kumar,Manoj Kumar,Riya Rauthan,Riya Rauthan,Namrata Sharma,Meghali Aich,Meghali Aich,Dipanjali Sinha,Dipanjali Sinha,Saumya Sharma,Saumya Sharma,Shivani Jain,Arjun Ray,Suman L. Jain,Sivaprakash Ramalingam,Sivaprakash Ramalingam,Souvik Maiti,Souvik Maiti,Debojyoti Chakraborty,Debojyoti Chakraborty +27 more
TL;DR: FnCas9 shows a very high specificity of binding to its intended targets and negligible binding to off-target loci, and it is proposed that it can be used for precise therapeutic genome editing for a wide variety of genetic disorders.
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Influence of Ionic Liquids on Thermodynamics of Small Molecule-DNA Interaction: The Binding of Ethidium Bromide to Calf Thymus DNA.
TL;DR: It is observed that presence of IL increased the stability of ctDNA without altering its structure, and the binding affinities Kbs for EB binding to ct DNA in the presence of 300 mM ILs are about half order of magnitude smaller than the Kbs in absence of ILs and correspond to a less favorable free energy.
Journal ArticleDOI
In vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice.
Chang Li,Aphrodite Georgakopoulou,Arpit Mishra,Sucheol Gil,R. David Hawkins,Evangelia Yannaki,André Lieber +6 more
TL;DR: The observations demonstrate that base editors delivered by HDAd5/35++ vectors represent a promising strategy for precise in vivo genome engineering for the treatment of hemoglobinopathies and no detectable editing was found at top-scored potential off-target genomic sites.