A
Arthur Thompson
Researcher at Norwich Research Park
Publications - 52
Citations - 4286
Arthur Thompson is an academic researcher from Norwich Research Park. The author has contributed to research in topics: Salmonella & Salmonella enterica. The author has an hindex of 27, co-authored 51 publications receiving 3945 citations. Previous affiliations of Arthur Thompson include Free University of Berlin & Norwich University.
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Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica.
TL;DR: The expression profile identified alterations in numerous virulence and SOS response genes and revealed unexpected findings concerning the biology of the Salmonella–macrophage interaction, suggesting that intracellular growth involves novel macrophage‐associated functions.
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Lag Phase Is a Distinct Growth Phase That Prepares Bacteria for Exponential Growth and Involves Transient Metal Accumulation
Matthew D. Rolfe,Matthew D. Rolfe,Christopher J. Rice,Sacha Lucchini,Carmen Pin,Arthur Thompson,Andrew D. S. Cameron,Mark Alston,Michael F. Stringer,Roy P. Betts,József Baranyi,Michael W. Peck,Jay C. D. Hinton,Jay C. D. Hinton +13 more
TL;DR: It is used inductively coupled plasma mass spectrometry (ICP-MS) to discover that iron, calcium, and manganese are accumulated by S. Typhimurium during lag phase, while levels of cobalt, nickel, and sodium showed distinct growth-phase-specific patterns.
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Butyrate Specifically Down-Regulates Salmonella Pathogenicity Island 1 Gene Expression
Inne Gantois,Richard Ducatelle,Frank Pasmans,Freddy Haesebrouck,Isabelle Hautefort,Arthur Thompson,Jay C. D. Hinton,F. Van Immerseel +7 more
TL;DR: In this paper, a comparative transcriptomic analysis of Salmonella enterica serovar enteritidis and salmonella serovars grown in medium supplemented with butyrate was performed.
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During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems.
Isabelle Hautefort,Arthur Thompson,S Eriksson-Ygberg,M L Parker,Sacha Lucchini,Vittoria Danino,Roy J. Bongaerts,N Ahmad,Mikael Rhen,Jay C. D. Hinton +9 more
TL;DR: This is the first report of the simultaneous transcription of all three Type Three Secretion Systems (T3SS) within an intracellular Salmonella population and it is discovered that S. Typhimurium strain SL1344 was strongly cytotoxic to epithelial cells after 6’h of infection.
Journal ArticleDOI
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence
Anne Rytkönen,John Poh,Junkal Garmendia,Cliona Boyle,Arthur Thompson,Mei Liu,Paul S. Freemont,Jay C. D. Hinton,David W. Holden +8 more
TL;DR: Ubiquitin-modified proteins accumulated in macrophages infected with Salmonella sseL mutant strains but to a lesser extent when infected with bacteria expressing active protein, demonstrating that SseL functions as a deubiquit inase in vivo.