A
Arti Dhar
Researcher at Birla Institute of Technology and Science
Publications - 50
Citations - 1299
Arti Dhar is an academic researcher from Birla Institute of Technology and Science. The author has contributed to research in topics: Oxidative stress & Medicine. The author has an hindex of 17, co-authored 36 publications receiving 1050 citations. Previous affiliations of Arti Dhar include University of Saskatchewan.
Papers
More filters
Journal ArticleDOI
Oxidative stress and aging: is methylglyoxal the hidden enemy?
Kaushik M. Desai,Tuanjie ChangT. Chang,Hui WangH. Wang,Ali Banigesh,Arti Dhar,Jianghai LiuJ. Liu,Ashley UntereinerA. Untereiner,Lingyun WuL. Wu +7 more
TL;DR: The potential role of MG in the aging process through increasing oxidative stress besides causing AGEs formation is discussed and specific and effective scavengers and crosslink breakers of MG and A GEs are being developed and can become potential treatments to slow the Aging process and prevent many diseases.
Journal ArticleDOI
Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats
TL;DR: Investigating the effects of chronic administration of MG on glucose tolerance and β-cell insulin secreting mechanism in 12-week-old male Sprague-Dawley rats found it induces biochemical and molecular abnormalities characteristic of type 2 diabetes and is a possible mediator of high carbohydrate-induced type 1 diabetes.
Journal ArticleDOI
Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose.
TL;DR: This data indicates that MG scavengers can prevent endothelial dysfunction induced by MG and high glucose concentrations and MG levels are elevated in spontaneously hypertensive rats and in diabetic patients.
Journal ArticleDOI
Methylglyoxal, protein binding and biological samples: Are we getting the true measure?
TL;DR: This work tested several protocols on different biological samples, which resulted in significant differences in MG values measured in a given sample, and recommended protocols that provide consistent values of MG in biological samples are recommended.
Journal ArticleDOI
Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats.
TL;DR: This work investigated whether alagebrium attenuated the acute effects of exogenous MG on plasma MG levels, glucose tolerance and distribution of administered MG in different organs in Sprague‐Dawley rats.