A
Arun Kanakkanthara
Researcher at Mayo Clinic
Publications - 22
Citations - 805
Arun Kanakkanthara is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Tubulin & Microtubule. The author has an hindex of 12, co-authored 22 publications receiving 663 citations. Previous affiliations of Arun Kanakkanthara include Victoria University of Wellington.
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Journal ArticleDOI
Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function
TL;DR: Drugs that target the microtubule will continue to have a major impact in oncology not only as anti-mitotics but also as potent inhibitors of interphase functions, and in future may also prove to be effective in reducing the consequences of neurodegenerative disease.
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Zampanolide, a potent new microtubule-stabilizing agent, covalently reacts with the taxane luminal site in tubulin α,β-heterodimers and microtubules.
Jessica J. Field,Benet Pera,Enrique Calvo,Ángeles Canales,Ángeles Canales,Didier Zurwerra,Chiara Trigili,Javier Rodríguez-Salarichs,Ruth Matesanz,Arun Kanakkanthara,St. John Wakefield,A. Jonathan Singh,Jesús Jiménez-Barbero,Peter T. Northcote,John H. Miller,Juan Antonio López,Ernest Hamel,Isabel Barasoain,Karl-Heinz Altmann,José Fernando Díaz +19 more
TL;DR: The results strongly support the existence of the luminal taxane site of microtubules in tubulin dimers and suggest that microtubule nucleation induction by MSAs may proceed through an allosteric mechanism.
Journal ArticleDOI
Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis.
Jessica J. Field,A. Jonathan Singh,Arun Kanakkanthara,Tu ikolongahau Halafihi,Peter T. Northcote,John H. Miller +5 more
TL;DR: Zampanolide, a 20-membered macrolide from a Tongan marine sponge, stabilizes microtubules and blocks cells in G(2)/M of the cell cycle and may be amenable to large-scale synthetic preparation.
Journal ArticleDOI
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation
Arun Kanakkanthara,Karthik B. Jeganathan,Jazeel F. Limzerwala,Darren J. Baker,Masakazu Hamada,Hyun Ja Nam,Willemijn H. van Deursen,Naomi Hamada,Ryan M. Naylor,Nicole A. Becker,Brian A. Davies,Janine H. van Ree,Georges Mer,Virginia Smith Shapiro,L. James Maher,David J. Katzmann,Jan M. van Deursen +16 more
TL;DR: Data reveal cyclin A2 as a mechanistically diverse regulator of DNA replication combining multifaceted kinase-dependent functions with a kinase–dependent, RNA binding–dependent role that ensures adequate repair of common replication errors.
Journal ArticleDOI
Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes
TL;DR: It is demonstrated that Pten, through the Dlg1-binding ability of its PDZ-BD, accumulates phosphorylated Eg5 at duplicated centrosomes to establish symmetrical bipolar spindles that properly segregate chromosomes, and suggest that this function contributes to tumour suppression.