A
Asbjørn Christophersen
Researcher at University of Oslo
Publications - 26
Citations - 759
Asbjørn Christophersen is an academic researcher from University of Oslo. The author has contributed to research in topics: Gluten & T-cell receptor. The author has an hindex of 12, co-authored 22 publications receiving 463 citations. Previous affiliations of Asbjørn Christophersen include Oslo University Hospital.
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Journal ArticleDOI
Distinct phenotype of CD4 + T cells driving celiac disease identified in multiple autoimmune conditions
Asbjørn Christophersen,Eivind G. Lund,Omri Snir,Elsa Sola,Elsa Sola,Chakravarthi Kanduri,Shiva Dahal-Koirala,Stephanie Zühlke,Øyvind Molberg,Øyvind Molberg,Paul J. Utz,Mina Rohani-Pichavant,Julia F. Simard,Cornelia L. Dekker,Knut E.A. Lundin,Knut E.A. Lundin,Ludvig M. Sollid,Mark M. Davis +17 more
TL;DR: It is found that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype, suggesting a way to characterize CD4 + T cells specific for disease-driving antigens in multiple autoimmune conditions.
Journal ArticleDOI
Disease-driving CD4+ T cell clonotypes persist for decades in celiac disease
Louise Fremgaard Risnes,Asbjørn Christophersen,Shiva Dahal-Koirala,Ralf Stefan Neumann,Geir Kjetil Sandve,Vikas Kumar Sarna,Knut E.A. Lundin,Shuo-Wang Qiao,Ludvig M. Sollid +8 more
TL;DR: It was observed that the recall response following oral gluten challenge was dominated by preexisting CD4+ T cell clonotypes, making up fixed repertoires that prevalently exhibit public features.
Journal ArticleDOI
HLA-DQ-gluten tetramer blood test accurately identifies patients with and without celiac disease in absence of gluten consumption.
Vikas Kumar Sarna,Vikas Kumar Sarna,Knut E.A. Lundin,Knut E.A. Lundin,Lars Mørkrid,Shuo-Wang Qiao,Shuo-Wang Qiao,Ludvig M. Sollid,Ludvig M. Sollid,Asbjørn Christophersen,Asbjørn Christophersen +10 more
TL;DR: An HLA-DQ-gluten tetramer-based assay that detects gluten-reactive T cells identifies patients with and without celiac disease with a high level of accuracy, regardless of whether the individuals are on a gluten-containing diet.
Journal ArticleDOI
KIR+CD8+ T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19
Jing Li,M. Zaslavsky,Yapeng Su,Jing Guo,Michael J. Sikora,Vincent van Unen,Asbjørn Christophersen,S. H. Chiou,Liang Chen,Jiefu Li,Xuhuai Ji,Julie Wilhelmy,Alana McSween,Brad A. Palanski,Venkata Vamsee Aditya Mallajosyula,Nathan A. Bracey,Gopal Krishna R. Dhondalay,Kartik Bhamidipati,Joy A. Pai,Lucas Kipp,Jeffrey Dunn,Stephen L. Hauser,Jorge R. Oksenberg,Ansuman T. Satpathy,William H. Robinson,Cornelia L. Dekker,Lars M. Steinmetz,Chaitan Khosla,Paul J. Utz,Ludvig M. Sollid,Yueh-hsiu Chien,James R. Heath,Nielsen Fernandez-Becker,Kari C. Nadeau,Naresha Saligrama,Mark M. Davis +35 more
TL;DR: It is found that CD8+ T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49+CD8+ regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases.
Journal ArticleDOI
Tetramer-visualized gluten-specific CD4+ T cells in blood as a potential diagnostic marker for coeliac disease without oral gluten challenge
Asbjørn Christophersen,Melinda Ráki,Elin Bergseng,Knut Ea Lundin,Jørgen Jahnsen,Ludvig M. Sollid,Shuo-Wang Qiao +6 more
TL;DR: Quantification of gut-homing, gluten-specific TEM in peripheral blood, visualized with human leukocyte antigen (HLA) -tetramers, may be used to distinguish CD patients from healthy individuals.