A
Ansuman T. Satpathy
Researcher at Stanford University
Publications - 146
Citations - 15143
Ansuman T. Satpathy is an academic researcher from Stanford University. The author has contributed to research in topics: Biology & T cell. The author has an hindex of 42, co-authored 105 publications receiving 9261 citations. Previous affiliations of Ansuman T. Satpathy include Harvard University & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues
M. Ryan Corces,Alexandro E. Trevino,Emily G. Hamilton,Peyton Greenside,Nicholas A Sinnott-Armstrong,Sam Vesuna,Ansuman T. Satpathy,Adam J. Rubin,Kathleen S. Montine,Beijing Wu,Arwa Kathiria,Seung Woo Cho,Maxwell R. Mumbach,Ava C. Carter,Maya Kasowski,Lisa A. Orloff,Viviana I. Risca,Anshul Kundaje,Paul A. Khavari,Thomas J. Montine,William J. Greenleaf,Howard Y. Chang +21 more
TL;DR: The Omni-ATAC protocol generates chromatin accessibility profiles from archival frozen tissue samples and 50-μm sections, revealing the activities of disease-associated DNA elements in distinct human brain structures.
Journal ArticleDOI
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Slava Epelman,Kory J. Lavine,Anna E. Beaudin,Dorothy K. Sojka,Javier A. Carrero,Boris Calderon,Thaddeus Brija,Emmanuel L. Gautier,Stoyan Ivanov,Ansuman T. Satpathy,Joel D. Schilling,Reto A. Schwendener,Ismail Sergin,Babak Razani,E. Camilla Forsberg,Wayne M. Yokoyama,Emil R. Unanue,Marco Colonna,Gwendalyn J. Randolph,Douglas L. Mann +19 more
TL;DR: Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis, and the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
Journal ArticleDOI
Clonal replacement of tumor-specific T cells following PD-1 blockade.
Kathryn E. Yost,Ansuman T. Satpathy,Daniel K. Wells,Yanyan Qi,Chunlin Wang,Robin Kageyama,Katherine McNamara,Jeffrey M. Granja,Kavita Y. Sarin,Ryanne A. Brown,Rohit Gupta,Christina Curtis,Samantha L. Bucktrout,Mark M. Davis,Anne Lynn S. Chang,Howard Y. Chang +15 more
TL;DR: Paired single-cell RNA and T cell receptor sequencing on 79,046 cells from site-matched tumors from patients with basal or squamous cell carcinoma before and after anti-PD-1 therapy demonstrates that pre-existing tumor-specific T cells may have limited reinvigoration capacity, and that the T cell response to checkpoint blockade derives from a distinct repertoire of T cell clones that may have just recently entered the tumor.
Journal ArticleDOI
CRISPR-engineered T cells in patients with refractory cancer
Edward A. Stadtmauer,Joseph A. Fraietta,Megan M. Davis,Adam D. Cohen,Kristy L. Weber,Eric Lancaster,Patricia A. Mangan,Irina Kulikovskaya,Minnal Gupta,Fang Chen,Lifeng Tian,Vanessa E. Gonzalez,Jun Xu,In-Young Jung,J. Joseph Melenhorst,Gabriela Plesa,Joanne Shea,Tina Matlawski,Amanda Cervini,Avery L. Gaymon,Stephanie Desjardins,Anne Lamontagne,January Salas-Mckee,Andrew D. Fesnak,Don L. Siegel,Bruce L. Levine,Julie K. Jadlowsky,Regina M. Young,Anne Chew,Wei-Ting Hwang,Elizabeth O. Hexner,Beatriz M. Carreno,Christopher L. Nobles,Frederic D. Bushman,Kevin R. Parker,Yanyan Qi,Ansuman T. Satpathy,Howard Y. Chang,Yangbing Zhao,Simon F. Lacey,Carl H. June +40 more
TL;DR: This first-in-human, phase 1 clinical trial was designed to test the safety and feasibility of multiplex CRISPR-Cas9 gene editing of T cells from patients with advanced, refractory cancer and found the persistence of the T cells expressing the engineered TCR was much more durable than in three previous clinical trials during which T cells were infused.
Journal ArticleDOI
The chromatin accessibility landscape of primary human cancers
M. Ryan Corces,Jeffrey M. Granja,Shadi Shams,Bryan H. Louie,Jose A. Seoane,Wanding Zhou,Tiago C. Silva,Tiago C. Silva,Clarice S. Groeneveld,Christopher K. Wong,Seung Woo Cho,Ansuman T. Satpathy,Maxwell R. Mumbach,Katherine A. Hoadley,A. Gordon Robertson,Nathan C. Sheffield,Ina Felau,Mauro A. A. Castro,Benjamin P. Berman,Louis M. Staudt,Jean C. Zenklusen,Peter W. Laird,Christina Curtis,William J. Greenleaf,Howard Y. Chang +24 more
TL;DR: These chromatin accessibility profiles identify cancer- and tissue-specific DNA regulatory elements that enable classification of tumor subtypes with newly recognized prognostic importance, and identify distinct TF activities in cancer based on differences in the inferred patterns of TF-DNA interaction and gene expression.