S
Stephanie Zühlke
Researcher at University of Oslo
Publications - 6
Citations - 162
Stephanie Zühlke is an academic researcher from University of Oslo. The author has contributed to research in topics: Antigen & CD38. The author has an hindex of 3, co-authored 4 publications receiving 87 citations. Previous affiliations of Stephanie Zühlke include Oslo University Hospital.
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Journal ArticleDOI
Distinct phenotype of CD4 + T cells driving celiac disease identified in multiple autoimmune conditions
Asbjørn Christophersen,Eivind G. Lund,Omri Snir,Elsa Sola,Elsa Sola,Chakravarthi Kanduri,Shiva Dahal-Koirala,Stephanie Zühlke,Øyvind Molberg,Øyvind Molberg,Paul J. Utz,Mina Rohani-Pichavant,Julia F. Simard,Cornelia L. Dekker,Knut E.A. Lundin,Knut E.A. Lundin,Ludvig M. Sollid,Mark M. Davis +17 more
TL;DR: It is found that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype, suggesting a way to characterize CD4 + T cells specific for disease-driving antigens in multiple autoimmune conditions.
Journal ArticleDOI
CD38 expression on gluten-specific T cells is a robust marker of gluten re-exposure in coeliac disease.
Stephanie Zühlke,Louise Fremgaard Risnes,Shiva Dahal-Koirala,Asbjørn Christophersen,Ludvig M. Sollid,Knut Ea Lundin +5 more
TL;DR: The optimal time points for monitoring therapy response in CeD after a three-day oral gluten challenge is four hours for plasma IL-2 or six to eight days for the frequency of tetramer’+ β7 +TEM cells, suggesting that this parameter is more suited for monitoring drug efficacy in clinical trials for CeD.
Journal ArticleDOI
A low FODMAP diet reduces symptoms in treated celiac patients with ongoing symptoms - a randomized controlled trial.
Frida van Megen,Gry Irene Skodje,Simon Lergenmuller,Stephanie Zühlke,Lars Aabakken,Marit B. Veierød,Christine Henriksen,Knut E.A. Lundin +7 more
TL;DR: A randomized controlled trial was performed from 2018 to 2019 in 70 adults with biopsy-proven celiac disease, where participants were randomized to either a low fermentable oligo-, di-, monosaccharides and polyols (FODMAP) diet or usual gluten-free diet (control) as discussed by the authors .
Journal ArticleDOI
Circulating CD103 + γδ and CD8 + T cells are clonally shared with tissue-resident intraepithelial lymphocytes in celiac disease
Louise Fremgaard Risnes,Louise Fremgaard Risnes,Linn M Eggesbø,Stephanie Zühlke,Stephanie Zühlke,Shiva Dahal-Koirala,Ralf Stefan Neumann,Knut E.A. Lundin,Knut E.A. Lundin,Asbjørn Christophersen,Ludvig M. Sollid,Ludvig M. Sollid +11 more
TL;DR: In this paper, the authors examined the clonal relationship between cells of blood and gut during gluten exposure and found extensive sharing between blood and colon TCRs even prior to a gluten challenge.
Journal ArticleDOI
Pathogenic T Cells in Celiac Disease Change Phenotype on Gluten Challenge: Implications for T-Cell-Directed Therapies
Asbjørn Christophersen,Asbjørn Christophersen,Stephanie Zühlke,Eivind G. Lund,Omri Snir,Shiva Dahal-Koirala,Louise Fremgaard Risnes,Louise Fremgaard Risnes,Jørgen Jahnsen,Jørgen Jahnsen,Knut E.A. Lundin,Knut E.A. Lundin,Ludvig M. Sollid,Ludvig M. Sollid +13 more
TL;DR: In this article, a 3-day gluten challenge was used to study the phenotype of gluten-specific CD4+ T cells in patients with celiac disease (CeD) and other autoimmune conditions.