Distinct phenotype of CD4 + T cells driving celiac disease identified in multiple autoimmune conditions
Asbjørn Christophersen,Eivind G. Lund,Omri Snir,Elsa Sola,Elsa Sola,Chakravarthi Kanduri,Shiva Dahal-Koirala,Stephanie Zühlke,Øyvind Molberg,Øyvind Molberg,Paul J. Utz,Mina Rohani-Pichavant,Julia F. Simard,Cornelia L. Dekker,Knut E.A. Lundin,Knut E.A. Lundin,Ludvig M. Sollid,Mark M. Davis +17 more
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TLDR
It is found that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype, suggesting a way to characterize CD4 + T cells specific for disease-driving antigens in multiple autoimmune conditions.Abstract:
Combining HLA-DQ-gluten tetramers with mass cytometry and RNA sequencing analysis, we find that gluten-specific CD4+ T cells in the blood and intestines of patients with celiac disease display a surprisingly rare phenotype. Cells with this phenotype are also elevated in patients with systemic sclerosis and systemic lupus erythematosus, suggesting a way to characterize CD4+ T cells specific for disease-driving antigens in multiple autoimmune conditions.read more
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