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Ashley Fetterman
Researcher at NovoBiotic Pharmaceuticals
Publications - 1
Citations - 301
Ashley Fetterman is an academic researcher from NovoBiotic Pharmaceuticals. The author has contributed to research in topics: Mycobacterium tuberculosis. The author has an hindex of 1, co-authored 1 publications receiving 240 citations.
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Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
Ekaterina Gavrish,Clarissa S. Sit,Shugeng Cao,Olga Kandror,Amy Spoering,Aaron J. Peoples,Losee Lucy Ling,Ashley Fetterman,Dallas Hughes,Anthony Bissell,Heather Torrey,Tatos Akopian,Andreas Mueller,Slava S. Epstein,Alfred L. Goldberg,Jon Clardy,Kim Lewis +16 more
TL;DR: It is shown that lassomycin binds to a highly acidic region of the ClpC1 ATPase complex and markedly stimulates its ATPase activity without stimulating ClpP1P2-catalyzed protein breakdown, which is essential for viability of mycobacteria.