A
Ashley Houchin
Publications - 3
Citations - 51
Ashley Houchin is an academic researcher. The author has contributed to research in topics: Antimicrobial & Stieglitz rearrangement. The author has an hindex of 3, co-authored 3 publications receiving 50 citations.
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Journal ArticleDOI
Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents
Charles Francavilla,Eddy Low,Satheesh K. Nair,Bum Tae Kim,Timothy P. Shiau,Dmitri Debabov,Chris Celeri,Nichole J Alvarez,Ashley Houchin,Ping Xu,Ron Najafi,Rakesh K. Jain +11 more
TL;DR: A series of backbone modified and sulfonic acid replacement analogs of the authors' topical, clinical candidate were synthesized and led to the identification of quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Journal ArticleDOI
Stieglitz rearrangement of N,N-dichloro-β,β-disubstituted taurines under mild aqueous conditions
Timothy P. Shiau,Ashley Houchin,Satheesh K. Nair,Ping Xu,Eddy Low,Ramin Najafi,Rakesh K. Jain +6 more
TL;DR: New topical anti-infectives comprised of N,N-dichloro-beta,beta-disubstituted taurines have been examined for structure-stability relationships (SSR) based upon various alkyl, heteroalkyl and cycloalkyle beta-substitutions.
Journal ArticleDOI
Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines
Eddy Low,Bum Tae Kim,Charles Francavilla,Timothy P. Shiau,Eric Douglas Turtle,Donogh J R O'Mahony,Nichole J Alvarez,Ashley Houchin,Ping Xu,Meghan Zuck,Chris Celeri,Mark B. Anderson,Ramin Najafi,Rakesh K. Jain +13 more
TL;DR: This study identified a new class of solution-stable and topical antimicrobial agents that are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group.