T
Timothy P. Shiau
Publications - 21
Citations - 165
Timothy P. Shiau is an academic researcher. The author has contributed to research in topics: Antimicrobial & Infectivity. The author has an hindex of 8, co-authored 21 publications receiving 160 citations.
Papers
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Journal ArticleDOI
Quaternary ammonium N,N-dichloroamines as topical, antimicrobial agents
Charles Francavilla,Eddy Low,Satheesh K. Nair,Bum Tae Kim,Timothy P. Shiau,Dmitri Debabov,Chris Celeri,Nichole J Alvarez,Ashley Houchin,Ping Xu,Ron Najafi,Rakesh K. Jain +11 more
TL;DR: A series of backbone modified and sulfonic acid replacement analogs of the authors' topical, clinical candidate were synthesized and led to the identification of quaternary ammonium N,N-dichloroamines as a new class of topical antimicrobial agents.
Journal ArticleDOI
N,N-Dichloroaminosulfonic acids as novel topical antimicrobial agents.
Eddy Low,Satheesh K. Nair,Timothy P. Shiau,Barbara Belisle,Dmitri Debabov,Chris Celeri,Meghan Zuck,Ron Najafi,N H Georgopapadakou,Rakesh K. Jain +9 more
TL;DR: 2-Dichloroamino-2-methyl-propane-1-sulfonic acid sodium salt, a stable derivative of endogenous N,N-dichlorotaurine, has been identified and is under development as a topical antimicrobial agent.
Journal ArticleDOI
Stieglitz rearrangement of N,N-dichloro-β,β-disubstituted taurines under mild aqueous conditions
Timothy P. Shiau,Ashley Houchin,Satheesh K. Nair,Ping Xu,Eddy Low,Ramin Najafi,Rakesh K. Jain +6 more
TL;DR: New topical anti-infectives comprised of N,N-dichloro-beta,beta-disubstituted taurines have been examined for structure-stability relationships (SSR) based upon various alkyl, heteroalkyl and cycloalkyle beta-substitutions.
Journal ArticleDOI
Novel N-chloroheterocyclic antimicrobials
Charles Francavilla,Eric Douglas Turtle,Bum Tae Kim,Donogh J R O'Mahony,Timothy P. Shiau,Eddy Low,Nichole J Alvarez,Chris Celeri,Louisa D'Lima,Lisa C Friedman,Francis S Ruado,Ping Xu,Meghan Zuck,Mark B. Anderson,Ramin Najafi,Rakesh K. Jain +15 more
TL;DR: Of the compounds examined, the N-chloroamine series were found superior over N- chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.
Patent
N-halogenated amino compounds and derivatives
TL;DR: In this article, active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and new uses of these compositions in therapy.