Showing papers by "Ashok M. Raichur published in 2020"
29 Sep 2020
TL;DR: Gal-AMSN can be used as a synthetic delivery vector to deliver the shDNA effectively for the treatment of HCV infection and significant reduction of viral RNA level was achieved in HCV-JFH1 infectious cell culture.
Abstract: DNA and RNA based antiviral strategies using nonviral vectors have shown better potential over the viral pathway due to the fewer chances of gene recombination and immunogenicity. In this work a me...
15 citations
TL;DR: In this paper, a point-of-care photoluminescence membrane strip (PoCPMS) was designed by coating the carbon nano dots (CNDs) on polyvinylidene difluoride (PVDF) membrane for the detection of dopamine (DA).
14 citations
TL;DR: The results suggested that fabrication of biopolymer-based nanoparticles with PC could provide greater insight to improve lutein bioavailability at enterocyte levels, to avoid age-related macular degeneration and other chronic diseases.
12 citations
16 Nov 2020
TL;DR: In this article, a facile route for converting molybdenum sulfide sheets into cotton-candy like aggregates which are then internalized easily by cells and then disassembled into sheets is presented.
Abstract: 2D materials such as graphene oxide and molybdenum sulfide exhibit certain properties such as photoluminescence, photothermal and photodynamic effects that have potential in diagnosing and treating cancer. However, their application is limited by low cellular uptake of the sheet-like structure. In this study, we present a facile route for converting MoS2 sheets into cotton-candy like aggregates which are then internalized easily by cells and then disassembled into sheets. Initially MoS2 sheets are produced from bulk MoS2 by albumin assisted exfoliation followed by assembly of sheets into aggregates by a desolvation technique. The MoS2 cotton-candy like aggregates can be taken up by cells more easily when compared to sheets because of low colloidal stability. Using a near infrared laser, the aggregates can be disintegrated into sheets within the cells. Two processes take place in this step. First, the photothermal properties of MoS2 aggregates can be used to kill cancerous cells. Secondly, on disintegration, the photoluminescence properties of MoS2 sheets can be utilized to image cancer cells. The cytotoxicity, phototoxicity and apoptosis of HeLa cells are reported here. A facile method for increasing the uptake of 2D materials into cells has been demonstrated.
1 citations