A
Ashwani Malhotra
Researcher at The Feinstein Institute for Medical Research
Publications - 136
Citations - 6320
Ashwani Malhotra is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Podocyte & Oxidative stress. The author has an hindex of 37, co-authored 135 publications receiving 5965 citations. Previous affiliations of Ashwani Malhotra include University of New Mexico & Temple University.
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Journal ArticleDOI
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
Shweta Rane,Minzhen He,Danish Sayed,Himanshu Vashistha,Ashwani Malhotra,Junichi Sadoshima,Dorothy E. Vatner,Stephen F. Vatner,Maha Abdellatif +8 more
TL;DR: It is reported here that miR-199a is acutely downregulated in cardiac myocytes on a decline in oxygen tension and this reduction is required for the rapid upregulation of its target, hypoxia-inducible factor (Hif)-1α.
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Angiotensin II induces apoptosis of adult ventricular myocytes in vitro.
TL;DR: Ligand binding of AT1receptors on myocytes triggers PMCD by a mechanism involving PKC-mediated increases in cytosolic calcium, which result in internucleosomal DNA fragmentation.
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MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths
Danish Sayed,Shweta Rane,Jacqueline Lypowy,Minzhen He,Ieng-Yi Chen,Himanshu Vashistha,Lin Yan,Ashwani Malhotra,Dorothy E. Vatner,Maha Abdellatif +9 more
TL;DR: It is proposed that an increase in miR-21 enhances the formation of various types of cellular protrusions through directly targeting and down-regulating SPRY2.
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The effect of streptozotocin-induced diabetes in rats on cardiac contractile proteins.
TL;DR: STZ diabetes causes a significant decrease in cardiac contractile protein ATPase activity, which may be related to altered proportions of myosin isoenzymes.
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Reversibility of diabetic cardiomyopathy with insulin in rats.
TL;DR: The findings indicate that previous work on diabetic rats can be extended to diabetic rabbits and suggest that chronic insulin therapy completely reverses the contractile alterations in hearts from these diabetic animals.