L
Lin Yan
Researcher at Rutgers University
Publications - 76
Citations - 4034
Lin Yan is an academic researcher from Rutgers University. The author has contributed to research in topics: Adenylyl cyclase & Pressure overload. The author has an hindex of 24, co-authored 71 publications receiving 3768 citations. Previous affiliations of Lin Yan include University of Medicine and Dentistry of New Jersey.
Papers
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Journal ArticleDOI
Drusen proteome analysis: An approach to the etiology of age-related macular degeneration
John W. Crabb,Masaru Miyagi,Xiaorong Gu,Karen G. Shadrach,K.A. West,Hirokazu Sakaguchi,Motohiro Kamei,Azeem Hasan,Lin Yan,Mary E. Rayborn,Robert G. Salomon,Joe G. Hollyfield +11 more
TL;DR: Data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation.
Journal ArticleDOI
Autophagy in chronically ischemic myocardium
Lin Yan,Dorothy E. Vatner,Song-Jung Kim,Hui Ge,Malthi Masurekar,William H. Massover,Guiping Yang,Yutaka Matsui,Junichi Sadoshima,Stephen F. Vatner +9 more
TL;DR: Testing the hypothesis that chronically ischemic myocardium induces autophagy, a cellular degradation process responsible for the turnover of unnecessary or dysfunctional organelles and cytoplasmic proteins, which could protect against the consequences of further ischemia found this mechanism to be a homeostatic mechanism.
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MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths
Danish Sayed,Shweta Rane,Jacqueline Lypowy,Minzhen He,Ieng-Yi Chen,Himanshu Vashistha,Lin Yan,Ashwani Malhotra,Dorothy E. Vatner,Maha Abdellatif +9 more
TL;DR: It is proposed that an increase in miR-21 enhances the formation of various types of cellular protrusions through directly targeting and down-regulating SPRY2.
Journal ArticleDOI
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Lin Yan,Dorothy E. Vatner,J. Patrick O'Connor,Andreas S. Ivessa,Hui Ge,Wei Chen,Shinichi Hirotani,Yoshihiro Ishikawa,Junichi Sadoshima,Stephen F. Vatner +9 more
TL;DR: A significant activation of the Raf/MEK/ERK signaling pathway and upregulation of cell protective molecules, including superoxide dismutase are demonstrated and suggest that AC is a fundamentally important mechanism regulating lifespan and stress resistance.
Journal ArticleDOI
Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy
Christophe Depre,Qian Wang,Lin Yan,Nadia Hedhli,Pallavi S. Peter,Li Chen,Chull Hong,Luc Hittinger,Bijan Ghaleh,Junichi Sadoshima,Dorothy E. Vatner,Stephen F. Vatner,Kiran Madura +12 more
TL;DR: The increase in proteasome expression and activity found during chronic pressure overload in myocardium submitted to higher stress is also required for the establishment of LVH.