다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.

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Circular RNAs are a large class of animal RNAs with regulatory potency

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Blood vessels constitute the first organ in the embryo and form the largest network in our body but, sadly, are also often deadly. When dysregulated, the formation of new blood vessels contributes to numerous malignant, ischemic, inflammatory, infectious and immune disorders. Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated.

Angiogenesis in health and disease.

Sometimes it is very difficult to find out accumulate information about techniques and tools of management accounting. It create hazardous for the searcher to find out the techniques and tools from here and there. Again sometimes some want to know the basics of various techniques and tools used in management accounting. To serve these duel purposes data on various management accounting techniques are collected from various books, journals and article and accumulate in this paper. This paper discusses 52 management accounting techniques and tools, which is a subsequent version of my previous paper on management accounting tools, in brief.

https://papers.ssrn.com/sol3/Delivery.cfm?abstractid=1654466

Fifty Two Tools of Management Accounting

Fanconi-Bickel syndrome (FBS) is a rare inherited glycogen storage disease (GSD) caused by defects in
 facilitative Glucose Transporter (GLUT2) gene that codes for the glucose transporter protein 2 expressed in hepatocytes, pancreatic beta cells, enterocytes, and renal tubular cells. The clinical picture is characterized by
 glycogen accumulation in liver and kidney resulting in hepatomegaly and nephromegaly, impaired utilization of
 glucose and galactose, proximal renal tubular acidosis, hypophosphatemia rickets, and short stature. This is an
 autosomal recessive disorder discovered in 1949 and the pathogenic mutation of GLUT 2 gene of hepatocytes, beta
 cells of pancreas and renal tubules were discovered in 1997.

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Fanconi Bickel Syndrome: A Rare Entity

The market of mobile phone of Bangladesh is a stiff competition market. There are lots of competitions among the service provider in this sector. And people have the query to know the current situation in the market. To know the current situation of the market I collect some raw data, like – the amount of subscriber of different operators, from the “Bangladesh Telecommunication Regulatory Committee (BTRC)” website and interpreted them to find out the performance of the various operators operating in this sector. Some other information is collected from the official website of the various companies. I use trend analysis and BCG matrix and other tools to find out performance of the companies using the raw data. At last by considering my analysis I draw a conclusion.

An Analysis of Market Performance of Mobile Phone Operators in Bangladesh

This study examined the effectiveness of the Annual Faculty Evaluations Process at an English language centre in the Middle Eastern context. It sought to determine to what extent this evaluation process helped the English language teachers improve their teaching practice. A mixed-method design was used to collect quantitative and qualitative data. The data were collected via teacher questionnaire & teacher interviews and triangulated via cross examination of the documents pertaining to the teacher evaluation policy and procedures used by the language centre. The findings of this case study revealed that the teachers believe that the process of annual faculty evaluation (AFE) has had a very positive impact on their professional development. However, the AFE process is quite rigid and does not take cultural diversity of the teachers into account. The report makes various recommendation in terms of teacher autonomy as well as participation in the evaluation process and using the three-track evaluation system (Danielson and McGreal, 2000) by the administration.

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An Investigation into Annual Faculty Evaluation Process of EFL Teachers in the Middle East: Challenges for Leadership & Management

A metabolic network of energy-sensing molecular pathways drives the biological ageing process. Regulating certain network elements can help decelerate the ageing process and ameliorate ageing assoc...

Asif Ahmed

Papers

Fifty Two Tools of Management Accounting

Fanconi Bickel Syndrome: A Rare Entity

An Analysis of Market Performance of Mobile Phone Operators in Bangladesh

An Investigation into Annual Faculty Evaluation Process of EFL Teachers in the Middle East: Challenges for Leadership & Management

In-silico screening of bioactive phytopeptides for novel anti-ageing therapeutics.