다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.

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Circular RNAs are a large class of animal RNAs with regulatory potency

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Blood vessels constitute the first organ in the embryo and form the largest network in our body but, sadly, are also often deadly. When dysregulated, the formation of new blood vessels contributes to numerous malignant, ischemic, inflammatory, infectious and immune disorders. Molecular insights into these processes are being generated at a rapidly increasing pace, offering new therapeutic opportunities that are currently being evaluated.

Angiogenesis in health and disease.

A recognition approach for handwritten Bengali numerals and its application for Bangladesh Postal system are presented in this paper. The approach consists of preprocessing, feature extraction and recognition. Using the canny edge detector the top left corner of the post-code box has been detected and the four handwritten numeral images have been segmented. Each image then goes through the steps of normalization, filtering and thinning. Kirsch mask has been used to get the edges through the horizontal, vertical, right and left diagonal. Principal component analysis (PCA) has been used for dimension reduction as the final feature vector consists of the four directional feature vector along with the normalized image. Then the output of the PCA is passed to a trained Support Vector Machine (SVM) to determine which class the input belongs to. Experiments demonstrate that the average recognition rate, error rate and reliability achieved by the proposed system are 92.5%, 7.5% and 92.5% respectively.

http://ieeexplore.ieee.org/iel5/4783035/4802963/04803019.pdf

An pproach to recognize handwritten bengali numerals for postal automation

The objective of preparing the paper is to learn the potentiality and problems in the implementation of crop insurance and livestock insurance in Bangladesh. In this paper I tried to analysis the early collapse of agricultural insurance in Bangladesh that was started in 1977. I also give a comparative analysis of agricultural insurance in various developed and developing countries, like - India, China, USA, UK, EU, Italy, Greece, Spain, Canada, Ireland and Australia. And finally give my recommendations.

Agricultural Insurance in Bangladesh; And Comparative Analysis of Various Countries

Background
Severe preeclampsia is associated with increased neutrophil activation and elevated serum soluble endoglin (sEng) and soluble Flt-1 (sFlt-1) in the maternal circulation. To dissect the contribution of systemic inflammation and anti-angiogenic factors in preeclampsia, we investigated the relationships between the circulating markers of neutrophil activation and anti-angiogenic factors in severe preeclampsia or systemic inflammatory state during pregnancy.

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Erratum to: The elevation in maternal anti-angiogenic factors is independent of markers of neutrophil activation and systemic inflammation in preeclampsia

http://portlandpress.com/clinsci/article-pdf/100/s44/19P/739184/cs100019pc.pdf

Nitric Oxide Released VIA Vegfr-1 Suppresses Vegfr-2 Mediated Endothelial Cell Growth and Regulates Angiogenesis

Effect of natural impurities induced in repeated melting is investigated on thermo-mechanical and reflectance characteristics of commercially available pure copper. Copper samples of three different material characteristics are prepared, which are obtained from direct copper ingot, from melted copper and finally from re-melted copper. Samples are then cold rolled in three different stages as well as age hardened by isochronal and isothermal annealing. Series of experiments are then conducted to measure the changes in microhardness, thermal conductivity, reflectance and microstructure of the samples as a function of with and without melting. Most of the thermal and mechanical properties are found to be affected quite significantly by the melting impurities especially when the samples are cold rolled together with age hardening. The reflectance spectrum is also found to be changed with the increase of impurities induced by repeated melting of copper.

Asif Ahmed

Papers

An pproach to recognize handwritten bengali numerals for postal automation

Agricultural Insurance in Bangladesh; And Comparative Analysis of Various Countries

Erratum to: The elevation in maternal anti-angiogenic factors is independent of markers of neutrophil activation and systemic inflammation in preeclampsia

Nitric Oxide Released VIA Vegfr-1 Suppresses Vegfr-2 Mediated Endothelial Cell Growth and Regulates Angiogenesis

Thermo-mechanical and optical characteristics of cold-rolled copper with natural melting impurities