A
Asish R. Chaudhuri
Researcher at University of Texas Health Science Center at San Antonio
Publications - 45
Citations - 3468
Asish R. Chaudhuri is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Oxidative stress & Tubulin. The author has an hindex of 24, co-authored 45 publications receiving 3211 citations. Previous affiliations of Asish R. Chaudhuri include Buck Institute for Research on Aging & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
The role of oxidative damage and stress in aging.
TL;DR: The most direct test of the Free Radical/Oxidative Stress Theory of Aging is to specifically alter the age-related increase in oxidative damage and determine how this alteration affects life span.
Journal ArticleDOI
Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy
Florian L. Muller,Wook Song,Yuhong Liu,Asish R. Chaudhuri,Asish R. Chaudhuri,Sandra Pieke-Dahl,Sandra Pieke-Dahl,Randy Strong,Randy Strong,Ting-Ting Huang,Charles J. Epstein,L. Jackson Roberts,Marie Csete,John A. Faulkner,Holly Van Remmen,Holly Van Remmen +15 more
TL;DR: A novel phenotype in mice lacking the major antioxidant enzyme, CuZn-superoxide dismutase (Sod1(-/-) mice), namely a dramatic acceleration of age-related loss of skeletal muscle mass is described.
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Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat
Viviana I. Pérez,Rochelle Buffenstein,Venkata Masamsetti,Shanique Leonard,Adam B. Salmon,James Mele,Blazej Andziak,Ting Yang,Yael H. Edrey,Bertrand Friguet,Walter F. Ward,Arlan Richardson,Asish R. Chaudhuri +12 more
TL;DR: It is hypothesized that age-related changes in protein structural stability, oxidation, and degradation are abrogated over the lifespan of the MR, and pivotal mechanistic interspecies differences may contribute to the divergent aging profiles and strongly implicate maintenance of protein stability and integrity in successful aging.
Journal ArticleDOI
High oxidative damage levels in the longest-living rodent, the naked mole-rat
Blazej Andziak,Timothy O'Connor,Wenbo Qi,Eric DeWaal,Anson Pierce,Asish R. Chaudhuri,Asish R. Chaudhuri,Holly Van Remmen,Rochelle Buffenstein +8 more
TL;DR: The findings strongly suggest that mechanisms other than attenuated oxidative stress explain the impressive longevity of the naked mole‐rat and that NMRs live an order of magnitude longer than predicted based on their body size.
Journal ArticleDOI
Overexpression of Mn Superoxide Dismutase Does Not Increase Life Span in Mice
Youngmok C. Jang,Viviana I. Pérez,Wook Song,Michael S. Lustgarten,Adam B. Salmon,James Mele,Wenbo Qi,Yuhong Liu,Hanyu Liang,Asish R. Chaudhuri,Asish R. Chaudhuri,Yuji Ikeno,Charles J. Epstein,Holly Van Remmen,Arlan Richardson +14 more
TL;DR: The data show that an approximately twofold overexpression of MnSOD throughout life in mice resulted in decreased lipid peroxidation, increased resistance against paraquat-induced oxidative stress, and decreased age-related decline in mitochondrial ATP production.