Astrid Obermayer

TL;DR: It is suggested that excessive NET formation represents the major factor underlying the gel-like structure of CF sputum and provide evidence that CF-NETs contain ectosome-like structures that could represent targets for future therapeutic approaches.

TL;DR: It is concluded that ROS interact with ETosis in a multidimensional manner, with influence on whether ETosis shows beneficial or detrimental effects, and the present evidence for ROS-independent ETosis is analyzed.

TL;DR: NET formation is not confined to exacerbation but also present in stable COPD and correlates with the severity of airflow limitation, infering that NETs are a major contributor to chronic inflammatory and lung tissue damage in COPD.

TL;DR: The structure of NETs found in induced sputum of patients with acutely exacerbated chronic obstructive pulmonary disease (COPD) is analysed using confocal laser microscopy and electron microscopy to conclude that NETosis is an integral part of COPD pathology and that release of ‘beads-on-a-string’ DNA studded with non-citrullinated histones is a common feature of in vivo NETosis.

TL;DR: Molecular techniques are used to provide a comprehensive characterization of MyoD and Myogenin expression during myogenic cell activation in embryos and larvae of brown trout, a fast‐growing salmonid with exceptionally large embryos, and suggest that Pax7 is expressed in myogenic progenitor cells that account for second‐ and third‐phase myogenesis.