Atsushi Kubo

TL;DR: The data suggest for the first time that PD-L1 status may be a new predictor of prognosis for patients with pancreatic cancer and provide the rationale for developing a novel therapy of targeting thePD-L/PD-1 pathway against this fatal disease.

TL;DR: These findings establish a developmental pathway in embryonic stem cell differentiation cultures that leads to efficient generation of cells with an immature hepatocytic phenotype.

TL;DR: HIF-1alpha appears to be a critical contributor to the progression of renal fibrosis and could be a useful target for its treatment.

TL;DR: The plasma levels of adrenomedullin (AM) and IL-8 levels correlated positively with Acute Physiology and Chronic Health Evaluation (APACHE) II score, peak multiple organ failure (MOF) score during the first month and prognosis in patients with septic shock, as did plasma IL-6 levels in Patients with traumatic shock.

TL;DR: The data suggest that hyperglycemia induces intraglomerular TGF-β1 mRNA expression in vivo, and that TGF -β1 overproduction may be associated with the progression of diabetic nephropathy.