V
Volker H. Haase
Researcher at Vanderbilt University
Publications - 130
Citations - 17283
Volker H. Haase is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Hypoxia-inducible factors & Kidney. The author has an hindex of 62, co-authored 121 publications receiving 15354 citations. Previous affiliations of Volker H. Haase include Veterans Health Administration & University of Pennsylvania.
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Journal ArticleDOI
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Thorsten Cramer,Yuji Yamanishi,Björn E. Clausen,Irmgard Förster,Rafal Pawlinski,Nigel Mackman,Volker H. Haase,Rudolf Jaenisch,Maripat Corr,Victor Nizet,Gary S. Firestein,Hans-Peter Gerber,Napoleone Ferrara,Randall S. Johnson +13 more
TL;DR: It is found that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a mechanism independent of VEGF, and its direct regulation of survival and function in the inflammatory microenvironment is demonstrated.
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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
James A. Trofatter,Mia MacCollin,Joni L. Rutter,Jill R. Murrell,Mabel P. Duyao,Dilys M. Parry,Roswell Eldridge,Nikolai Kley,Anil G. Menon,K Pulaski,Volker H. Haase,Christine Ambrose,David J. Munroe,Catherine Bove,Jonathan L. Haines,Robert L. Martuza,Marcy E. MacDonald,Bernd R. Seizinger,M. Priscilla Short,Alan Buckler,James F. Gusella +20 more
TL;DR: A candidate gene for the NF2 tumor suppressor that has suffered nonoverlapping deletions in DNA from two independent NF2 families and alterations in meningiomas from two unrelated NF2 patients is identified.
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Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Debra F. Higgins,Kuniko Kimura,Wanja M. Bernhardt,Nikita Shrimanker,Yasuhiro Akai,Bernd Hohenstein,Yoshihiko Saito,Randall S. Johnson,Matthias Kretzler,Clemens D. Cohen,Kai-Uwe Eckardt,Masayuki Iwano,Volker H. Haase +12 more
TL;DR: Clinical and genetic evidence is provided that activation of HIF-1 signaling in renal epithelial cells is associated with the development of chronic renal disease and may promote fibrogenesis by increasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilitating EMT.
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Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts.
Merav Socolovsky,Hyung-song Nam,Mark D. Fleming,Volker H. Haase,Carlo Brugnara,Harvey F. Lodish +5 more
TL;DR: It is shown that some adult Stat5a (-/-)5b(-/-) mice have a near-normal hematocrit but are deficient in generating high erythropoietic rates in response to stress, and many adult Stat 5a-5b-5a mice have persistent anemia despite a marked compensatory expansion in their erythroblast tissue.
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The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
Ying Wang,Chao Wan,Lianfu Deng,Ximeng Liu,Xuemei Cao,Shawn R. Gilbert,Mary L. Bouxsein,Marie Claude Faugere,Robert E. Guldberg,Louis C. Gerstenfeld,Volker H. Haase,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens,Thomas L. Clemens +14 more
TL;DR: It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.