H
Hideo Yagita
Researcher at Juntendo University
Publications - 956
Citations - 76611
Hideo Yagita is an academic researcher from Juntendo University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 137, co-authored 946 publications receiving 70623 citations. Previous affiliations of Hideo Yagita include Niigata University & University of California, San Francisco.
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PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
TL;DR: Combination blockade of the PD-1/PD-L1- and CTLA-4-negative costimulatory pathways allows tumor-specific T cells that would otherwise be inactivated to continue to expand and carry out effector functions, thereby shifting the tumor microenvironment from suppressive to inflammatory.
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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Yasutoshi Agata,Akemi Kawasaki,Hiroyuki Nishimura,Yasumasa Ishida,Takeshi Tsubata,Hideo Yagita,Tasuku Honjo +6 more
TL;DR: The results suggest that the expression of thePD-1 antigen is tightly regulated and induced by signal transduction through the antigen receptor and do not exclude the possibility that the PD- 1 antigen may play a role in clonal selection of lymphocytes although PD-1 expression is not required for the common pathway of apoptosis.
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Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma.
Tyler R. Simpson,Fubin Li,Welby Montalvo-Ortiz,Manuel A. Sepulveda,Katharina Bergerhoff,Frederick Arce,Claire Roddie,Jake Y. Henry,Hideo Yagita,Jedd D. Wolchok,Karl S. Peggs,Jeffrey V. Ravetch,James P. Allison,Sergio A. Quezada +13 more
TL;DR: Anti–CTLA-4 antibody induces selective depletion of T reg cells within tumor lesions in a manner that is dependent on the presence of Fc gamma receptor-expressing macrophages within the tumor microenvironment.
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ATP drives lamina propria T H 17 cell differentiation
Koji Atarashi,Junichi Nishimura,Tatsuichiro Shima,Yoshinori Umesaki,Masahiro Yamamoto,Masaharu Onoue,Hideo Yagita,Naoto Ishii,Richard J. Evans,Kenya Honda,Kiyoshi Takeda +10 more
TL;DR: It is shown that adenosine 5′-triphosphate (ATP) that can be derived from commensal bacteria activates a unique subset of lamina propria cells, CD70highCD11clow cells, leading to the differentiation of TH17 cells, and the critical role of ATP is underscored.
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Expression of Programmed Death 1 Ligands by Murine T Cells and APC
Tomohide Yamazaki,Hisaya Akiba,Hideyuki Iwai,Hironori Matsuda,Mami Aoki,Yuka Tanno,Tahiro Shin,Haruo Tsuchiya,Drew M. Pardoll,Ko Okumura,Miyuki Azuma,Hideo Yagita +11 more
TL;DR: B7-H1 was broadly expressed on the surface of mouse tumor cell lines while the expression of B7-DC was rather restricted, and the inducible expression of PD-1 ligands on both T cells and APCs may suggest new paradigms ofPD-1-mediated immune regulation.