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Atsushi Saito
Researcher at Nara Institute of Science and Technology
Publications - 15
Citations - 2421
Atsushi Saito is an academic researcher from Nara Institute of Science and Technology. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 6, co-authored 15 publications receiving 2226 citations. Previous affiliations of Atsushi Saito include Health Science University & University of Miyazaki.
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Journal ArticleDOI
Autophagy Is Activated for Cell Survival after Endoplasmic Reticulum Stress
Maiko Ogata,Shin-ichiro Hino,Atsushi Saito,Keisuke Morikawa,Shinichi Kondo,Soshi Kanemoto,Tomohiko Murakami,Manabu Taniguchi,Ichiro Tanii,Kazuya Yoshinaga,Sadao Shiosaka,James A. Hammarback,Fumihiko Urano,Kazunori Imaizumi +13 more
TL;DR: It is found that the autophagy system is activated as a novel signaling pathway in response to ER stress and played important roles in cell survival after ER stress.
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Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue
TL;DR: It is found that endoplasmic reticulum (ER) stress is induced by free fatty acid (FFA)-mediated reactive oxygen species (ROS) generation and up-regulated gene expression of inflammatory cytokines in 3T3-L1 adipocytes.
Journal ArticleDOI
BBF2H7, a novel transmembrane bZIP transcription factor, is a new type of endoplasmic reticulum stress transducer.
Shinichi Kondo,Atsushi Saito,Shin-ichiro Hino,Tomohiko Murakami,Maiko Ogata,Soshi Kanemoto,Satoshi Nara,Akinori Yamashita,Kazuya Yoshinaga,Hideaki Hara,Kazunori Imaizumi +10 more
TL;DR: It is reported that BBF2H7 (BBF2 human homolog on chromosome 7), an ER-resident transmembrane protein with the bZIP domain in the cytoplasmic portion and structurally homologous to OASIS, is cleaved at the membrane in response to ER stress.
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Cleavage of the membrane-bound transcription factor OASIS in response to endoplasmic reticulum stress.
Tomohiko Murakami,Shinichi Kondo,Maiko Ogata,Maiko Ogata,Soshi Kanemoto,Soshi Kanemoto,Atsushi Saito,Atsushi Saito,Akio Wanaka,Kazunori Imaizumi +9 more
TL;DR: It is shown that OASIS is processed by Site‐1 and ‐2 proteases (S1P and S2P), enzymes that reside at the Golgi apparatus and process activating transcription factor 6 (ATF6), in response to ER stress.
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Endoplasmic reticulum stress response in dendrites of cultured primary neurons.
TL;DR: It is shown that ER stress sensors, inositol-requiring 1 (IRE1), PKR-like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) exist in the ER of both soma and dendrites in primary mouse neurons and that under ER stress conditions, GRP78/BiP and phosphorylated eIF2alpha are induced.