A
Atsushi Tokunaga
Researcher at Hyogo College of Medicine
Publications - 47
Citations - 5602
Atsushi Tokunaga is an academic researcher from Hyogo College of Medicine. The author has contributed to research in topics: Dorsal root ganglion & Nerve injury. The author has an hindex of 33, co-authored 47 publications receiving 5374 citations.
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Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with aδ/c‐fibers and colocalization with trk receptors
Kimiko Kobayashi,Tetsuo Fukuoka,Koichi Obata,Hiroki Yamanaka,Yi Dai,Atsushi Tokunaga,Koichi Noguchi +6 more
TL;DR: Heterogeneity of TRPM8 and TRPA1 expression by subpopulations of primary afferent neurons, which may result in the difference of cold‐sensitive primary afferential neurons in sensitivity to chemicals such as menthol and capsaicin and nerve growth factor, is suggested.
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Activating Transcription Factor 3 (ATF3) Induction by Axotomy in Sensory and Motoneurons: A Novel Neuronal Marker of Nerve Injury
Hiroaki Tsujino,Eiji Kondo,Tetsuo Fukuoka,Yi Dai,Atsushi Tokunaga,Kenji Miki,Kazuo Yonenobu,Takahiro Ochi,Koichi Noguchi +8 more
TL;DR: It is concluded that ATF3 is specifically induced in sensory and motoneurons in the spinal cord following nerve injury and should be regarded as an unique neuronal marker of nerve injury in the nervous system.
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TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
Koichi Obata,Hirokazu Katsura,Toshiyuki Mizushima,Hiroki Yamanaka,Kimiko Kobayashi,Yi Dai,Tetsuo Fukuoka,Atsushi Tokunaga,Makoto Tominaga,Koichi Noguchi +9 more
TL;DR: It is demonstrated that an NGF-induced TRPA1 increase in sensory neurons via p38 activation is necessary for cold hyperalgesia, which might provide a fruitful strategy for treating cold hyperAlgesia caused by inflammation and nerve damage.
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Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization
Yi Dai,Koichi Iwata,Tetsuo Fukuoka,Eiji Kondo,Atsushi Tokunaga,Hiroki Yamanaka,Toshiya Tachibana,Yi Liu,Koichi Noguchi +8 more
TL;DR: PERK inPrimary afferents by noxious stimulationin vivo showed distinct characteristics of expression and may be correlated with the functional activity of primary afferent neurons.
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Role of Mitogen-Activated Protein Kinase Activation in Injured and Intact Primary Afferent Neurons for Mechanical and Heat Hypersensitivity after Spinal Nerve Ligation
Koichi Obata,Hiroki Yamanaka,Kimiko Kobayashi,Yi Dai,Toshiyuki Mizushima,Hirokazu Katsura,Tetsuo Fukuoka,Atsushi Tokunaga,Koichi Noguchi +8 more
TL;DR: It is demonstrated that the L5 SNL induces differential activation of MAPK in injured and uninjured DRG neurons and, furthermore, that MAPK activation in the primary afferents may participate in generating pain hypersensitivity after partial nerve injury.