Showing papers in "Molecular and Cellular Neuroscience in 2000"

TL;DR: It is concluded that ATF3 is specifically induced in sensory and motoneurons in the spinal cord following nerve injury and should be regarded as an unique neuronal marker of nerve injury in the nervous system.

TL;DR: The cellular distribution of pro- and anti-inflammatory molecules in human parkinsonian and neurologically normal substantia nigra and caudate-putamen postmortem is examined to determine the balance of these molecules that is likely to be decisive in determining neuronal survival or demise.

TL;DR: The results reveal the functional role of SK channels with defined subunit compositions in some neurons and open the way to the identification of the molecular determinants of AHP currents in many brain regions.

TL;DR: The first use of neural progenitor cells in the diseased adult retina is described, demonstrating the differentiation of substantial numbers of new neurons within the mature dystrophic retina.

TL;DR: The differential distribution of two tetrodotoxin resistant (TTXr) voltage-gated sodium channels SNS (PN3) and SNS2 (NaN) in rat primary sensory neurons has been investigated and at least four different classes of A- and C-fiber DRG neurons exist, therefore, with respect to expression of these sodium channels.

TL;DR: Interruption of both primary afferent input by dorsal root rhizotomy and descending input by rostral spinal cord hemisection produced minor changes in CB1-ir, suggesting that the majority of CB1 expression is on spinal interneurons.

TL;DR: It is reported that Phox2b has a wider and overlapping role, in that it is required for the differentiation of all noradrenergic centers in the brain, including the locus coeruleus.

TL;DR: The molecular mechanism that controls oligodendrocyte lineage progression is operated by at least two signal pathways, which interfere either with proliferation and/or differentiation of oligod endocrine progenitors.

TL;DR: The inhibition of the NGF-activated phosphoinositide 3-kinase (PI3K)-PKB/Akt1 survival pathway by the cell permeable analog C2-ceramide provides a novel mechanism for induction of apoptosis by ceramide in nerve-derived cells.

TL;DR: The characterization of a second highly related aspartic proteinase, Asp1, is described as a second β-secretase candidate and has the N-terminal sequence ALEP… , indicating that it has lost the prodomain.

TL;DR: The recent data are considered and it is suggested that calcium and the MAPK cascade might be required for very distinct growth cone functions.

TL;DR: Compared to normal nerve, there was a marked increase in the neurite-promoting activity of the degenerated nerve, and this activity was not increased significantly by subsequent MMP treatment, suggesting that degradation of inhibitory CSPG by the MMPs contributes to the growth-promoted properties of degenerated nerves.

TL;DR: It is concluded that NBN/ART, similarly to GDNF, is a potent neuroprotective factor for the nigrostriatal DA neurons in vivo.

TL;DR: The results suggest that the cad11-mediated junctions may modulate synaptic efficacy, confining its dynamic changes to a limited range, or these junctions are required for normal development of synaptic organization in the hippocampus.

TL;DR: Evidence is provided suggesting a possible function for agrin in Alzheimer's disease brain, and immunocytochemical studies demonstrate agrin's presence within senile plaques and cerebrovascular amyloid deposits, and agrin immunostained capillaries exhibit pathological alterations in AD brain.

TL;DR: It is shown that cleavage of proNRGs is complex and generates several cell-bound truncated fragments and that proNRG beta 2a was relatively resistant to processing compared to pro NRG beta 4a which was processed more efficiently than ProNRG alpha 2a.

TL;DR: A model of remyelination is suggested in which PDGF is involved in the initial phase of oligodendrocyte progenitor recruitment, while IGF-I and TGF-beta 1 trigger the differentiation of the recruited cells into myelinating oligodendedrocytes.

TL;DR: A systematic examination ofADAM gene expression in rodent CNS is provided, showing the first quantitative characterization of ADAM mRNA distribution therein, and suggests versatile roles for ADAMs in the adult CNS.

TL;DR: Results indicate that InsP(3)R-mediated store depletion does not underlie TRP and TRPL activation in Drosophila photoreceptors, and using the specific TRP channel blocker La(3+) it is demonstrated that both TRP or TRPL channel functions were unaffected.

TL;DR: The mouse Gfra4 is characterized and it is shown that it undergoes developmentally regulated alternative splicing in several tissues, and GFRalpha4 expression may restrict the inherited cancer syndrome multiple endocrine neoplasia type 2, associated with mutations in RET, to these cells.

TL;DR: The results suggest that Homer-1c increases the cell surface expression of the metabotropic glutamate receptor type 1alpha by increasing its retention in the plasma membrane.

TL;DR: It is demonstrated that genetically perpetuated HNSCs, once transplanted, find residence in the host brain, where they differentiate, generating mature neural cells in theHost, chimeric, adult mammalian brain.

TL;DR: Cut and ligation injuries caused a prolonged upregulation of CHL1 mRNA (and GAP-43 mRNA), indicating that reconnection with target tissues may be required to signal the return to control levels.

TL;DR: Data illustrate that motility and differentiation of OPP involve the combinatorial action of PSA-NCAM, molecules of the ECM and their receptors, and growth factors.

TL;DR: In situ analysis of developing embryonic nervous tissue showed nna1 was highly expressed in differentiating neurons, but not proliferating populations, and Nna1 is predicted to be a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP binding motif.

TL;DR: It is reported that death of camptothecin-treated caspase 3-deficient neurons cultured from E16 embryos is delayed and that no significant increase in survival is observed with cotreatment with the general caspases inhibitor BAF, and hypothesize that the delayed death which occurs in the absence of casp enzyme 3 activity may be due to mitochondrial dysfunction.

TL;DR: The results suggest that targeting or use of the AGAAAAGA peptide may represent a therapeutic opportunity for controlling prion disease.

TL;DR: The notion that endogenously expressed BDNF is neuroprotective and that BDNF signaling may have an important role in preventing brain damage after transient ischemia is supported.