A
Attila Sik
Researcher at University of Birmingham
Publications - 83
Citations - 10205
Attila Sik is an academic researcher from University of Birmingham. The author has contributed to research in topics: Hippocampal formation & Inhibitory postsynaptic potential. The author has an hindex of 36, co-authored 79 publications receiving 9491 citations. Previous affiliations of Attila Sik include Hungarian Academy of Sciences & University of Pécs.
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Journal ArticleDOI
Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons
István Katona,Beáta Sperlágh,Attila Sik,Attila Käfalvi,E. Sylvester Vizi,Ken Mackie,Tamás F. Freund +6 more
TL;DR: The results suggest that cannabinoid-mediated modulation of hippocampal interneuron networks operate largely via presynaptic receptors on CCK-immunoreactive basket cell terminals, the likely mechanism by which both endogenous and exogenous CB1 ligands interfere with hippocampal network oscillations and associated cognitive functions.
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Sharp wave-associated high-frequency oscillation (200 Hz) in the intact hippocampus: network and intracellular mechanisms
TL;DR: The findings indicate that the intracellularly recorded fast oscillatory rhythm is not solely dependent on membrane currents intrinsic to the CA1 pyramidal cells but it is a network driven phenomenon dependent upon the participation of inhibitory interneurons.
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Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
Jeffrey A. M. Coull,Dominic Boudreau,Karine Bachand,Steven A. Prescott,Steven A. Prescott,Francine Nault,Francine Nault,Attila Sik,Paul De Koninck,Yves De Koninck,Yves De Koninck +10 more
TL;DR: Evidence is presented for a novel mechanism of disinhibition following peripheral nerve injury that involves a trans-synaptic reduction in the expression of the potassium–chloride exporter KCC2, and the consequent disruption of anion homeostasis in neurons of lamina I of the superficial dorsal horn, one of the main spinal nociceptive output pathways.
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GABAergic Cells Are the Major Postsynaptic Targets of Mossy Fibers in the Rat Hippocampus
TL;DR: Granule cells developed distinct types of terminals to affect interneurons and pyramidal cells and they innervated more inhibitory than excitatory cells, which may explain the physiological observations that increased activity of granule cells suppresses the overall excitability of the CA3 recurrent system.
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Hippocampal CA1 interneurons: an in vivo intracellular labeling study
TL;DR: Fast spiking interneurons in the CA1 area of the dorsal hippocampus were recorded from and filled with biocytin in anesthetized rats to indicate that interneURons with distinct axonal targets have differential functions in shaping the physiological patterns of theCA1 network.