A
Axel P. N. Themmen
Researcher at Erasmus University Rotterdam
Publications - 175
Citations - 20649
Axel P. N. Themmen is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Anti-Müllerian hormone & Receptor. The author has an hindex of 61, co-authored 174 publications receiving 19236 citations. Previous affiliations of Axel P. N. Themmen include Beckman Coulter.
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Journal ArticleDOI
Anti‐Müllerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment
Christien Weenen,Joop S.E. Laven,Anne R.M. von Bergh,Mark Cranfield,Nigel P. Groome,Jenny A. Visser,Piet Kramer,Bart C.J.M. Fauser,Axel P. N. Themmen +8 more
TL;DR: In the human AMH expression follows a similar pattern as compared to the mouse and rat, suggesting an important role of AMH in folliculogenesis.
Journal ArticleDOI
Serum anti-mullerian hormone levels: a novel measure of ovarian reserve
I A J van Rooij,Frank J.M. Broekmans,E.R. te Velde,Bart C.J.M. Fauser,László F.J.M.M Bancsi,F. H. De Jong,Axel P. N. Themmen +6 more
TL;DR: Poor response in IVF, indicative of a diminished ovarian reserve, is associated with reduced baseline serum AMH concentrations, and it appears that AMH can be used as a marker for ovarian ageing.
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Antimüllerian hormone serum levels: a putative marker for ovarian aging.
TL;DR: Serum concentrations of antimüllerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change, and concentration correlate with the number of antral follicles and age and less strongly with FSH level.
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Control of primordial follicle recruitment by anti-Müllerian hormone in the mouse ovary.
Alexandra L. L. Durlinger,Piet Kramer,Bas Karels,Frank H. de Jong,Jan Th. J. Uilenbroek,J. Anton Grootegoed,Axel P. N. Themmen +6 more
TL;DR: It is found that ovaries of 25-day- and 4-month-old AMH null females, compared to those of wild-type females, contain more preantral and small antral follicles, and AMH plays an important role inPrimordial follicle recruitment, such that more primordial follicles are recruited in AMHnull mice than in wild- type mice.
Journal ArticleDOI
Regulation of ovarian function: the role of anti-Müllerian hormone
TL;DR: This review describes several in vivo and in vitro studies showing that AMH participates in two critical selection points of follicle development: it inhibits the recruitment of primordial follicles into the pool of growing follicles and also decreases the responsiveness ofgrowing follicles to FSH.