Axel Ring

TL;DR: Overall, fatty acid uptake represents a continuous flow involving the following: dissociation from albumin by membrane proteins with high affinity for fatty acids; passive flip-flop across the phospholipid bilayer; binding to FABPc and caveolin-1 at the cytosolic plasma membrane; and intracellular trafficking via FABpc and/or caveolae to sites of metabolic disposition.

TL;DR: It is suggested that plasma membrane fatty acid translocase (FAT/CD36) mediates raft-dependent LCFA uptake by regulating surface availability of FAT/ CD36 within plasma membrane DRMs.

TL;DR: It is shown that wild-type mouse embryonic fibroblasts and caveolin-1 knockout MEFs, which are devoid of caveolae, have comparable overall expression of FAT/CD36 protein but altered subcellular FAT/ CD36 localization and function, and that caveolin 1 may influence fatty acid uptake by regulating surface availability of FAT-CD36.

TL;DR: This review will discuss how lipid rafts might be involved in the uptake process and how the candidate proteins for fatty acid uptake FAT/CD36 and the FATP proteins interact with these domains, and the functional role of FATPs in general.

TL;DR: A critical involvement of lipid rafts in the binding and uptake of LCFA into 3T3-L1 adipocytes is found and FAT/CD36 was found to be present in this DRM fraction as well, suggesting a pivotal role in lipid raft-dependent LCFA uptake.