Ayako Shiraki

TL;DR: Results suggest that Mn targets immature granule cells causing apoptosis and neuronal mismigration, and sustained increases in immature reelin-synthesizing GABAergic interneurons may represent continued aberration in neurogenesis and following migration to cause an excessive response for overproduction of immature granules cells through to the adult stage.

TL;DR: It is suggested that whole brain fixation with methacarn retains advantages for global analyses of mRNAs and polypeptides in rodent studies and subsequent tissue sampling using punch-biopsy devices for gene expression analysis in rats.

TL;DR: Findings indicate epigenetic mechanisms as mediators, through which Mn exposure modulates neurogenesis involving both granule cell lineage and GABAergic interneurons with long-lasting and stable repercussions.

TL;DR: Subpopulation changes in GABAergic interneuron subpopulations by hypothyroidism may be the signature of aberrant neurogenesis even at the adult stage.

TL;DR: Glycidol caused axon injury in the central and peripheral nervous systems of adult rats, suggesting that glycidol targets the newly generating nerve terminals of immature granule cells, resulting in the suppression of late-stage hippocampal neurogenesis.