Makoto Shibutani

TL;DR: It is suggested that TBBPA did not exert developmental brain effects, while HBCD did, and 100 ppm was determined to be the no-observed-adverse-effect level of HBCd from changes in thyroid parameters at the adult stage by maternal exposure.

TL;DR: This article recommends standardized terms for classifying changes observed in tissues of the mouse and rat central (CNS) and peripheral (PNS) nervous systems as well as principal toxicant-induced findings.

TL;DR: All effects, except for impaired brain development, might be linked to systemic growth retardation, and the brain morphometric methods employed in this study may be useful to evaluate the potency of chemicals to induce hypothyroidism-related brain retardation.

TL;DR: The results suggest that tumor‐specific imaging by ICG involves non‐specific delivery of the dye to tissues followed by preferential tumor cellular uptake and retention, which is driven by passive tumor cell‐targeting and endocytic activity of tumor cells in association with the disruption of their tight junctions.

TL;DR: It is suggested that renal toxicity would not be induced by treatment with minimum amounts of CdCl2 for periods longer than 8 months, although accumulation ofCd might gradually progress.