Aylla N L M Silva

TL;DR: The results showed that high levels of HbF were primarily influenced by alleles of BCL11A and HMIP and to a lesser extent by rs748214 Gγ-globin (HBG2) gene promoter, and reinforce the suggestion that studies of association between genetic modifiers and clinical and laboratory manifestations in Brazil must be controlled by ancestry.

TL;DR: The data obtained in Anajás showed no differential resistance vivax malaria among Duffy-negative and Duffy-positive individuals, reinforcing the idea that this parasite is rapidly evolving, being able to use other receptors than Duffy to invade the erythrocytes.

TL;DR: The results emphasize the need to monitor G6PD deficiency for the use of primaquine in the routine care of the Afro-descendant communities of the Trombetas, Erepecuru and Cumná rivers, evaluating the risks of hemolytic crisis in case of recurrence of malaria in the region.

TL;DR: The profile of β-thal mutations found in northern Brazil is different from those described in other regions of the country, and the European contribution in the southeast and south was largely made up of immigrants of other nationalities, such as Italian and Spanish, in addition to Portuguese.

TL;DR: The allelic frequencies among indigenous indicate that the majority of associations observed with type 2 diabetes in continental populations can be replicated in native Amazonians, and the genetic risk scores calculated for T2D in indigenous are high and similar to those calculated for Americans and East Asians.