Ayushi Chaurasiya

TL;DR: It is shown that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this interaction reduces invasion by 80%, paving the way for developing peptide and small-molecules that inhibit the protein−protein interactions, individually or in toto, leading to abrogation of the invasion process.

TL;DR: In this article, the authors showed that inhibition of pathogen-mediated host NAD+ modulation is a way forward for regulation of infection, synthesized and screened some novel compounds that showed inhibition of NAD+-glycohydrolase activity and pathogen infection in the nanomolar range.

TL;DR: This study identified a novel anti-malarial peptide that could be used in combination with other antimalarials for blocking the invasion of Plasmodium falciparum.

TL;DR: In this paper , the authors reported the rational repurposing of the anti-hepatitis C virus drug, alisporivir, a nonimmunosuppressive analog of cyclosporin A, against artemisinin-resistant strains of P. falciparum.

TL;DR: The hijacking of the host SUMOylation pathway by L. donovani toward the suppression of host immune responses and facilitation of host autophagy to potentially facilitate its survival can provide a starting point for the design and development of novel therapeutic interventions to combat leishmaniasis.