A
Azim M Mohamedali
Researcher at King's College London
Publications - 57
Citations - 2451
Azim M Mohamedali is an academic researcher from King's College London. The author has contributed to research in topics: Gene mutation & Myeloid. The author has an hindex of 23, co-authored 57 publications receiving 2230 citations. Previous affiliations of Azim M Mohamedali include National Health Service & University of Cambridge.
Papers
More filters
Journal ArticleDOI
TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.
Austin G. Kulasekararaj,Alexander E. Smith,Syed A Mian,Azim M Mohamedali,Pramila Krishnamurthy,Pramila Krishnamurthy,Nicholas Lea,Joop Gaken,Coralie Pennaneac'h,Robin M. Ireland,B. Czepulkowski,Sabine Pomplun,Judith C. W. Marsh,Judith C. W. Marsh,Ghulam J. Mufti,Ghulam J. Mufti +15 more
TL;DR: Patients with mutant TP53 had a paucity of mutations in other genes implicated in myeloid malignancies, however clones increased in non‐responders and persisted at relapse, suggesting an early occurrence of TP53 mutations.
Journal ArticleDOI
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.
Alexander E. Smith,Azim M Mohamedali,Austin G. Kulasekararaj,ZiYi Lim,Joop Gaken,Nicholas Lea,Bartlomiej Przychodzen,Syed A Mian,Erick E. Nasser,Claire Shooter,Nigel Westwood,Corinna Strupp,Norbert Gattermann,Jaroslaw P. Maciejewski,Ulrich Germing,Ghulam J. Mufti +15 more
TL;DR: There was no significant prognostic association between TET2 mutations and World Health Organization subtypes, International Prognostic Scoring System score, cytogenetic status, or transformation to acute myeloid leukemia.
Journal ArticleDOI
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome
Austin G. Kulasekararaj,Austin G. Kulasekararaj,Jie Jiang,Jie Jiang,Alexander E. Smith,Alexander E. Smith,Azim M Mohamedali,Azim M Mohamedali,Syed A Mian,Shreyans Gandhi,Joop Gaken,B. Czepulkowski,Judith C. W. Marsh,Judith C. W. Marsh,Ghulam J. Mufti,Ghulam J. Mufti +15 more
TL;DR: It is postulated that somatic mutations are present in a subset of AA, and predict malignant transformation, and nearly one-fifth of AA patients harbor mutations in genes typically seen in myeloid malignancies that predicted for later transformation to MDS.
Journal ArticleDOI
Prognostic impact of SNP array karyotyping in myelodysplastic syndromes and related myeloid malignancies.
Ramon V. Tiu,Lukasz P. Gondek,Christine L. O'Keefe,Paul Elson,Jungwon Huh,Azim M Mohamedali,Austin G. Kulasekararaj,Anjali S. Advani,Ronald Paquette,Alan F. List,Mikkael A. Sekeres,Michael A. McDevitt,Ghulam J. Mufti,Jaroslaw P. Maciejewski +13 more
TL;DR: The significant diagnostic and prognostic contributions of SNP-A-detected defects in MDS and related diseases underscore the utility of SNP/SNP-A when combined with MC in hematologic malignancies.
Journal ArticleDOI
Prevalence and prognostic significance of allelic imbalance by single nucleotide polymorphism analysis in low risk myelodysplastic syndromes
Azim M Mohamedali,Joop Gaken,Natalie A. Twine,Wendy Ingram,Nigel Westwood,Nicholas Lea,Janet Hayden,Nora Donaldson,Carlo Aul,Norbert Gattermann,A. Giagounidis,Ulrich Germing,Alan F. List,Ghulam J. Mufti +13 more
TL;DR: It is shown, for the first time, that SNP microarray analysis in low-risk MDS patients reveals hitherto unrecognized UPD and CN changes that may allow stratification of these patients for early therapeutic interventions.