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Austin G. Kulasekararaj
Researcher at King's College London
Publications - 213
Citations - 6476
Austin G. Kulasekararaj is an academic researcher from King's College London. The author has contributed to research in topics: Medicine & Paroxysmal nocturnal hemoglobinuria. The author has an hindex of 34, co-authored 173 publications receiving 4671 citations. Previous affiliations of Austin G. Kulasekararaj include University of London & University of Cambridge.
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Journal ArticleDOI
Guidelines for the diagnosis and management of adult aplastic anaemia.
Sally Killick,Nick Bown,Jamie Cavenagh,Inderjeet Dokal,Theodora Foukaneli,Anita J. Hill,Peter Hillmen,Robin M. Ireland,Austin G. Kulasekararaj,Ghulam J. Mufti,John A. Snowden,Sujith Samarasinghe,Anna Wood,Judith C. W. Marsh +13 more
TL;DR: The authors thank Sally B. Killick, Nick Bown, Jamie Cavenagh, Inderjeet Dokal, Theodora Foukaneli, Peter Hillmen, Robin Ireland, Austin Kulasekararaj, Ghulam Mufti, John A Snowden, Sujith Samarasinghe and Anna Wood for their help.
Journal ArticleDOI
TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression
Martin Jädersten,Leonie Saft,Alexander E. Smith,Austin G. Kulasekararaj,Sabine Pomplun,Gudrun Göhring,Anette Hedlund,Robert Hast,Brigitte Schlegelberger,Anna Porwit,Eva Hellström-Lindberg,Ghulam J. Mufti +11 more
TL;DR: It is demonstrated that TP53 mutated populations may occur at an early disease stage in almost a fifth of low-risk MDS patients with del(5q) and could indicate a previously unrecognized heterogeneity of the disease which may significantly affect clinical decision making.
Journal ArticleDOI
TP53 mutations in myelodysplastic syndrome are strongly correlated with aberrations of chromosome 5, and correlate with adverse prognosis.
Austin G. Kulasekararaj,Alexander E. Smith,Syed A Mian,Azim M Mohamedali,Pramila Krishnamurthy,Pramila Krishnamurthy,Nicholas Lea,Joop Gaken,Coralie Pennaneac'h,Robin M. Ireland,B. Czepulkowski,Sabine Pomplun,Judith C. W. Marsh,Judith C. W. Marsh,Ghulam J. Mufti,Ghulam J. Mufti +15 more
TL;DR: Patients with mutant TP53 had a paucity of mutations in other genes implicated in myeloid malignancies, however clones increased in non‐responders and persisted at relapse, suggesting an early occurrence of TP53 mutations.
Journal ArticleDOI
Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value.
Alexander E. Smith,Azim M Mohamedali,Austin G. Kulasekararaj,ZiYi Lim,Joop Gaken,Nicholas Lea,Bartlomiej Przychodzen,Syed A Mian,Erick E. Nasser,Claire Shooter,Nigel Westwood,Corinna Strupp,Norbert Gattermann,Jaroslaw P. Maciejewski,Ulrich Germing,Ghulam J. Mufti +15 more
TL;DR: There was no significant prognostic association between TET2 mutations and World Health Organization subtypes, International Prognostic Scoring System score, cytogenetic status, or transformation to acute myeloid leukemia.
Journal ArticleDOI
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome
Austin G. Kulasekararaj,Austin G. Kulasekararaj,Jie Jiang,Jie Jiang,Alexander E. Smith,Alexander E. Smith,Azim M Mohamedali,Azim M Mohamedali,Syed A Mian,Shreyans Gandhi,Joop Gaken,B. Czepulkowski,Judith C. W. Marsh,Judith C. W. Marsh,Ghulam J. Mufti,Ghulam J. Mufti +15 more
TL;DR: It is postulated that somatic mutations are present in a subset of AA, and predict malignant transformation, and nearly one-fifth of AA patients harbor mutations in genes typically seen in myeloid malignancies that predicted for later transformation to MDS.