A
Azzeddine Dakhama
Researcher at National Jewish Health
Publications - 103
Citations - 5668
Azzeddine Dakhama is an academic researcher from National Jewish Health. The author has contributed to research in topics: CD8 & Inflammation. The author has an hindex of 46, co-authored 103 publications receiving 5400 citations. Previous affiliations of Azzeddine Dakhama include University of British Columbia & Laval University.
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Journal ArticleDOI
Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-β
Anthony Joetham,Katsuyuki Takada,Christian Taube,Nobuaki Miyahara,S. Matsubara,Toshiyuki Koya,Yeong Ho Rha,Azzeddine Dakhama,Erwin W. Gelfand +8 more
TL;DR: These data identify naturally occurring lung CD4+CD25+ T cells as capable of regulating lung allergic responses in an IL-10- and TGF-β-dependent manner.
Journal ArticleDOI
IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization
Mika J. Mäkelä,Arihiko Kanehiro,L. Borish,Azzeddine Dakhama,Joan E. Loader,Anthony Joetham,Zhou Xing,Manel Jordana,Gary L. Larsen,Erwin W. Gelfand +9 more
TL;DR: It is demonstrated in a model of allergic sensitization that mice deficient in IL-10 (IL-10-/-) develop a pulmonary inflammatory response but fail to exhibit airway hyperresponsiveness in both in vitro and in vivo assessments of lung function.
Journal ArticleDOI
The Role of IL-13 in Established Allergic Airway Disease
Christian Taube,Catherine Duez,Zhi Hua Cui,Katsuyuki Takeda,Yeong Ho Rha,Jung Won Park,Annette Balhorn,Debra D. Donaldson,Azzeddine Dakhama,Erwin W. Gelfand +9 more
TL;DR: It is demonstrated that targeting IL-13 alone regulates airway responses when administrated to mice with established allergic airway disease, even when administered before rechallenge of mice in which allergic disease had been previously established.
Journal ArticleDOI
Effector CD8^+ T cells mediate inflammation and airway hyper-responsiveness
Nobuaki Miyahara,Bradley J. Swanson,Katsuyuki Takeda,Christian Taube,Satoko Miyahara,Taku Kodama,Azzeddine Dakhama,Vanessa L. Ott,Erwin W. Gelfand +8 more
TL;DR: Data suggest an important role for effector CD8+ T cells in the development of AHR and airway inflammation, which may be associated with their Tc2-type cytokine production and their capacity to migrate into the lung.
Journal ArticleDOI
Algal growth enhancement by bacteria: Is consumption of photosynthetic oxygen involved?
TL;DR: It is suggested that, apart from a CO2 supply, aerobic bacteria can promote algal growth by reducing the photosynthetic oxygen tension within the microenvironment of the algal cells, thereby creating more favorable conditions for optimal PhotosyntheticAlgal growth.