C
Christian Taube
Researcher at University of Mainz
Publications - 233
Citations - 7454
Christian Taube is an academic researcher from University of Mainz. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 45, co-authored 155 publications receiving 6330 citations. Previous affiliations of Christian Taube include Leiden University Medical Center & Medical University of South Carolina.
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Journal ArticleDOI
Interferon-Regulatory Factor 4 Is Essential for the Developmental Program of T Helper 9 Cells
Valérie Staudt,Evita Bothur,Matthias Klein,Karen Lingnau,Sebastian Reuter,Nadine Grebe,Bastian Gerlitzki,Markus Hoffmann,Alexander Ulges,Christian Taube,Nina Dehzad,Marc Becker,Michael Stassen,Andrea Steinborn,Michael Lohoff,Hansjörg Schild,Edgar Schmitt,Tobias Bopp +17 more
TL;DR: The data clearly demonstrate the central function of IRF4 in the development of Th9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma.
Journal ArticleDOI
Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory t cells
Isabelle C. Arnold,Nina Dehzad,Sebastian Reuter,Helen Martin,Burkhard Becher,Christian Taube,Anne Müller +6 more
TL;DR: Experimental evidence is provided for a beneficial effect of H. pylori colonization on the development of allergen-induced asthma by utilizing mouse models of allergic airway disease induced by ovalbumin or house dust miteAllergen to experimentally examine a possible inverse correlation between H.pylori and asthma.
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DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori–specific immune tolerance, and asthma protection
Mathias Oertli,Malin Sundquist,Iris Hitzler,Daniela B. Engler,Isabelle C. Arnold,Sebastian Reuter,Joachim Maxeiner,Malin Hansson,Christian Taube,Marianne Quiding-Järbrink,Anne Müller +10 more
TL;DR: The results indicate that tolerogenic reprogramming of DCs ensures the persistence of H. pylori and protects against allergic asthma in a process that requires IL-18.
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Naturally Occurring Lung CD4+CD25+ T Cell Regulation of Airway Allergic Responses Depends on IL-10 Induction of TGF-β
Anthony Joetham,Katsuyuki Takada,Christian Taube,Nobuaki Miyahara,S. Matsubara,Toshiyuki Koya,Yeong Ho Rha,Azzeddine Dakhama,Erwin W. Gelfand +8 more
TL;DR: These data identify naturally occurring lung CD4+CD25+ T cells as capable of regulating lung allergic responses in an IL-10- and TGF-β-dependent manner.
Journal ArticleDOI
The Role of IL-13 in Established Allergic Airway Disease
Christian Taube,Catherine Duez,Zhi Hua Cui,Katsuyuki Takeda,Yeong Ho Rha,Jung Won Park,Annette Balhorn,Debra D. Donaldson,Azzeddine Dakhama,Erwin W. Gelfand +9 more
TL;DR: It is demonstrated that targeting IL-13 alone regulates airway responses when administrated to mice with established allergic airway disease, even when administered before rechallenge of mice in which allergic disease had been previously established.