B
B D Given
Researcher at University of Chicago
Publications - 22
Citations - 3140
B D Given is an academic researcher from University of Chicago. The author has contributed to research in topics: Insulin & Diabetes mellitus. The author has an hindex of 16, co-authored 18 publications receiving 3010 citations.
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Journal ArticleDOI
Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects.
TL;DR: In obesity, although hypersecretion of insulin can be documented, the temporal pattern of secretion is largely unaltered, which suggests that the functioning beta cell mass is enhance, but normal regulatory mechanisms influencing secretion are still operative.
Journal ArticleDOI
Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.
Kenneth S. Polonsky,B D Given,Lawrence Hirsch,H Tillil,E. T. Shapiro,C Beebe,Bruce H. Frank,John A Galloway,E. Van Cauter +8 more
TL;DR: Data suggest that profound alterations in the amount and temporal organization of stimulated insulin secretion may be important in the pathophysiology of beta-cell dysfunction in diabetes.
Journal ArticleDOI
Quantitative study of insulin secretion and clearance in normal and obese subjects.
Kenneth S. Polonsky,B D Given,Lawrence Hirsch,E. T. Shapiro,H Tillil,C Beebe,John A Galloway,Bruce H. Frank,Theodore Karrison,E. Van Cauter +9 more
TL;DR: Under basal, fasting conditions and during ingestion of a mixed diet, the hyperinsulinemia of obesity results predominantly from increased insulin secretion, and a reduction in insulin clearance may contribute to the greater increase in peripheral insulin concentrations that are characteristic of the obese state.
Journal ArticleDOI
Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients.
Kenneth S. Polonsky,J. Licinio-Paixao,B D Given,W. Pugh,Paul A. Rue,J Galloway,Theodore Karrison,B Frank +7 more
TL;DR: The non-steady infusion rate of BHCP could be accurately calculated from peripheral C- peptide concentrations using a two-compartment mathematical model when model parameters were derived from the C-peptide decay curve in each subject.
Journal ArticleDOI
A structurally abnormal insulin causing human diabetes
Howard S. Tager,B D Given,D. Baldwin,Mary E. Mako,James J Markese,Arthur H. Rubenstein,Jerrold M. Olefsky,Masashi Kobayashi,O. Kolterman,Russel Poucher +9 more
TL;DR: Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation.