B
Babette Kögel
Researcher at Grünenthal GmbH
Publications - 13
Citations - 910
Babette Kögel is an academic researcher from Grünenthal GmbH. The author has contributed to research in topics: Analgesic & Opioid. The author has an hindex of 12, co-authored 13 publications receiving 823 citations.
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Journal ArticleDOI
Cebranopadol: A Novel Potent Analgesic Nociceptin/Orphanin FQ Peptide and Opioid Receptor Agonist
Klaus Linz,Thomas Christoph,Thomas M. Tzschentke,Thomas Koch,Klaus Schiene,Michael Gautrois,Wolfgang P. Schröder,Babette Kögel,Horst Beier,Werner Englberger,Stefan Schunk,Jean De Vry,Ulrich Jahnel,Stefanie Frosch +13 more
TL;DR: Cebranopadol, by its combination of agonism at NOP and opioid receptors, affords highly potent and efficacious analgesia in various pain models with a favorable side effect profile.
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Broad analgesic profile of buprenorphine in rodent models of acute and chronic pain
TL;DR: It is concluded that buprenorphine shows a broad analgesic profile and offers the opportunity to treat different pain conditions, including neuropathic pain.
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Mechanistic and functional differentiation of tapentadol and tramadol
Robert B. Raffa,Helmut Buschmann,Thomas Christoph,Gary Eichenbaum,Werner Englberger,Christopher M. Flores,Torsten Hertrampf,Babette Kögel,Klaus Schiene,Wolfgang Strasburger,Rolf Terlinden,Thomas M. Tzschentke +11 more
TL;DR: Tapentadol, a schedule-II controlled substance, is well-suited for pain conditions requiring a strong opioid component—and it has the benefit of greater gastrointestinal tolerability compared to classical strong opioids.
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The mu-opioid receptor agonist/noradrenaline reuptake inhibition (MOR-NRI) concept in analgesia: the case of tapentadol.
TL;DR: It is suggested that tapentadol is the first representative of a proposed new class of analgesics, MOR–NRI, such that relatively moderate activity at the two target sites (MOR and noradrenaline reuptake transporter) is sufficient to produce strong analgesic effects.
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Interaction of μ-opioid receptor agonists and antagonists with the analgesic effect of buprenorphine in mice
TL;DR: This study investigated the interaction potential with several full μ‐agonists in the tail‐flick test in mice and examined the reversibility of buprenorphine antinociception by different μ‐opioid receptor antagonists.