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Robert B. Raffa
Researcher at Temple University
Publications - 421
Citations - 13471
Robert B. Raffa is an academic researcher from Temple University. The author has contributed to research in topics: Opioid & Analgesic. The author has an hindex of 49, co-authored 413 publications receiving 12369 citations. Previous affiliations of Robert B. Raffa include Thomas Jefferson University & University of Arizona.
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Journal Article
Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic.
Robert B. Raffa,Elmar Friderichs,Wolfgang Reimann,Richard P. Shank,Ellen E. Codd,Jeffry L. Vaught +5 more
TL;DR: The results suggest that tramadol-induced antinociception is mediated by opioid (mu) and nonopioid (inhibition of monoamine uptake) mechanisms, and is consistent with the clinical experience of a wide separation between analgesia and typical opioid side effects.
Journal ArticleDOI
Opioids and the management of chronic severe pain in the elderly: Consensus statement of an international expert panel with focus on the six clinically most often used world health organization step III opioids (Buprenorphine, Fentanyl, Hydromorphone, Methadone, Morphine, Oxycodone)
Joseph V. Pergolizzi,Rainer H. Böger,Keith Budd,Albert Dahan,Serdar Erdine,Guy Hans,Hans G. Kress,Richard M. Langford,Rudolf Likar,Robert B. Raffa,Paola Sacerdote +10 more
TL;DR: The criteria for selecting analgesics for pain treatment in the elderly include, but are not limited to, overall efficacy, overall side‐effect profile, onset of action, drug interactions, abuse potential, and practical issues, such as cost and availability of the drug, as well as the severity and type of pain.
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Insulin receptors and insulin action in the brain: review and clinical implications.
TL;DR: The present review summarizes the structure, distribution and function of mammalian brain insulin receptors and the possible implications for central nervous system disorders.
Journal Article
Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol.
Robert B. Raffa,Elmar Friderichs,Wolfgang Reimann,Richard P. Shank,E E Codd,Jeffry L. Vaught,Henry I. Jacoby,Norma Selve +7 more
TL;DR: A rational explanation for the coexistence of dual components to tramadol-induced antinociception appears to be related to the different, but complementary and interactive, pharmacologies of its enantiomers and might form the basis for understanding its clinical profile.
Journal Article
Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception.
TL;DR: Investigation of a diverse group of opioids revealed that structurally identifiable subgroups inhibited the neuronal reuptake of these monoamines, suggesting a broader role for the combination of mu opioid affinity and 5-hydroxytryptamine uptake inhibition in the activity of other antinociceptive agents.