Badreddin Edris

TL;DR: All human solid tumor cells require CD47 expression to suppress phagocytic innate immune surveillance and elimination, showing that CD47 is a commonly expressed molecule on all cancers, its function to blockphagocytosis is known, and blockade of its function leads to tumor cell phagcytosis and elimination.

TL;DR: Interference with CD47 increases phagocytosis of two human LMS cell lines, LMS04 and LMS05, in vitro, which suggests that treatment with anti-CD47 antibodies not only reduces primary tumor size but can also be used to inhibit the development of, or to eliminate, metastatic disease.

TL;DR: This study provides the first large survey of long non-coding RNA expression within a panel of solid cancers and also identifies a number of novel transcribed regions differentially expressed across distinct cancer types that represent candidate biomarkers for future research.

TL;DR: The data show that the CSF1 response signature is consistently seen in a subset of breast carcinomas and correlates with biological features of the tumor, which may facilitate the development of personalized therapy for patients most likely to benefit from CSF 1-targeted treatments.

TL;DR: In this analysis that combined gene expression profiling, aCGH and IHC, distinct molecular LMS subtypes are characterized, provided insight into their pathogenesis, and identified prognostic biomarkers.