Maddalena Adorno

TL;DR: All human solid tumor cells require CD47 expression to suppress phagocytic innate immune surveillance and elimination, showing that CD47 is a commonly expressed molecule on all cancers, its function to blockphagocytosis is known, and blockade of its function leads to tumor cell phagcytosis and elimination.

TL;DR: Two common oncogenic lesions, mutant-p53 and Ras, selected in early neoplasms to promote growth and survival, also prefigure a cellular set-up with particular metastasis proclivity by TGFbeta-dependent inhibition of p63 function.

TL;DR: This study defines a regulative ubiquitination step controlling Smads that is parallel to those impinging on R-Smad phosphorylation, and points to Smad4 monoubiquitinated and deubiquitination as a way for cells to set their TGFbeta responsiveness.

TL;DR: These metastatic cancer models, combined with noninvasive imaging techniques, constitute an integrated approach that could be applied to dissect the molecular mechanisms underlying the dissemination of metastatic CSCs (MCSCs) and to explore therapeutic strategies targeting MCSCs in general or to evaluate individual patient tumor cells and predict response to therapy.

TL;DR: It is proposed that Ectodermin is a key switch in the control of TGF-beta gene responses during early embryonic development and cell proliferation.