B
Bakthavatchalam Velavan
Researcher at University of Madras
Publications - 6
Citations - 143
Bakthavatchalam Velavan is an academic researcher from University of Madras. The author has contributed to research in topics: Transforming growth factor & Cancer. The author has an hindex of 4, co-authored 5 publications receiving 96 citations.
Papers
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Journal ArticleDOI
Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review
Ashok Kumar Pandurangan,Thomas Divya,Kalaivani Kumar,Vadivel Dineshbabu,Bakthavatchalam Velavan,Ganapasam Sudhandiran +5 more
TL;DR: This review summarizes CRC pathogenesis and the related cell death and signal transduction pathways, which include apoptosis, necroptosis and autophagy, to determine cell fate in CRC.
Journal ArticleDOI
Nano-chemotherapeutic efficacy of (-) -epigallocatechin 3-gallate mediating apoptosis in A549 cells: Involvement of reactive oxygen species mediated Nrf2/Keap1signaling.
TL;DR: It is demonstrated that native and nano EGCG induces apoptosis through the involvement of ROS leading to loss in mitochondrial membrane potential and renders better efficacy against lung cancer cells.
Journal ArticleDOI
Regulation of Transforming Growth Factor-β/Smad-mediated Epithelial-Mesenchymal Transition by Celastrol Provides Protection against Bleomycin-induced Pulmonary Fibrosis.
TL;DR: It is found that celastrol regulates EMT through the inhibition of heat shock protein 90 (HSP 90) and the results indicate that EMT is a crucial phenomenon for the progression of fibrosis, and Celastrol provides protection against PF through the regulation of EMT.
Journal ArticleDOI
Radical dendrimers: Synthesis, anti-tumor activity and enhanced cytoprotective performance of TEMPO free radical functionalized polyurethane dendrimers
TL;DR: The efficacy of the dendrimers was demonstrated through decrease in free radicals and their enhanced cytoprotective performance over N-acetyl cysteine standard used was confirmed.
Book ChapterDOI
Protease-Activated Receptor Signaling in Lung Pathology
TL;DR: Modulation of PAR signaling might open novel avenues in the treatment interventions in a number of respiratory conditions at least in part to reduce the burden of the diseases.