Showing papers in "Biochemical and Biophysical Research Communications in 2018"

TL;DR: The salt-tolerance mechanism of plants is described from four aspects: plant osmotic stress, ion toxicity, oxidative stress, and salt tolerance genes to help in studies to reveal the mechanism of plant salt tolerance, and screen high efficiency and quality salt tolerance crops.

TL;DR: GSDME switches chemotherapy drug-induced caspase-3 dependent apoptosis into pyroptosis in gastric cancer cells, and GSDME knockout by CRISPR-Cas9 switched 5-FU induced pyroPTosis into apoptosis in SGC-7901.

TL;DR: It is shown that FTO, but not other m6A modification genes including METTL3, METTL14 and ALKBH5, was the major dysregulated factor responsible for aberrant m 6A modification in LUSC.

TL;DR: This review discusses the metabolic reprogramming of tumor cells with special focus on lipid metabolism, and addresses the lipid turnover machinery in the tumor cell, especially the lipophagic pathway.

TL;DR: Hsa_circ_0001649 was aberrantly downregulated in CCA tissues and cells, and this downregulation was associated with tumor size and differentiation grade in C CA.

TL;DR: The circ_0067934/miR-1324/FZD5/β-catenin signaling axis might serve as a promising therapeutic target for HCC intervention.

TL;DR: The first life forms evolved in a highly reducing environment, which makes the concept of "reductive stress" somewhat redundant, and the battle for iron between bacteria and animal hosts continues today, a much greater daily threat to the authors' survival than "oxidative stress" and "redox stress".

TL;DR: It is demonstrated that STAT3 is a positive regulator of ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cell lines and lysosome-dependent cell death by pharmacological inhibition and genetic silencing of STAT3 through small molecules or siRNA blocked erastin-induced ferroPTosis in PDAC cells.

TL;DR: Hsa_circRNA_103809 was found to be significantly down regulated in CRC tissues and cell lines and compared with paired adjacent non-tumorous tissues and normal FHC cells.

TL;DR: This study showed the biogenic, environmentally friendly and cost-effective synthesis and characterization of the silver nanoparticles, and revealed the spherical shape of the particles.

TL;DR: It is demonstrated that circHIPK3 contributes to glioma progression through targeting miR-654 from IGF2BP3 and implies circHipK3 might be a potential target for gli cancer therapy, and CCK8 and transwell assays illustrated that IGF 2BP3 overexpression could reverse the effects of IGF2 BP3 depletion.

TL;DR: The role of bHLH in plants in response to stresses such as drought, salt and cold stress is discussed and new ideas and targets for the prevention and treatment of plant stress resistance are provided.

TL;DR: This study discovers that hsa_circ_0001564 acts as miR-29c-3p sponge to mediate the tumorigenicity, which could act as a potential biomarker for the osteosarcoma and provide a novel insight for competing endogenous RNAs (ceRNAs) mechanism in osteosARcoma.

TL;DR: Interestingly, the increased iron overload and lipid peroxidation observed in either rats with HF or H9c2 cells incubated with ISO were significantly blocked by puerarin administration, suggesting a new mechanism of puer Karin as a potential therapy for HF.

TL;DR: The findings illustrated a novel hsa_circRNA_103809/miR-4302/ZNF121/MYC regulatory signaling pathway in lung cancer progression, which could serve as a prognostic biomarker for patients with lung cancer.

TL;DR: This study indicated that hsa_circ_0008039 exerted oncogenic roles in breast cancer and suggested the hsa-circ/miR-432-5p/E2F3 axis might be a potential therapeutic target.

TL;DR: ShED exhibited higher proliferative activity and levels of bFGF and BMP-2 gene expression compared with BMMSCs and DPSCs, suggesting that SHED may be a useful cell source for application in bone regeneration treatments.

TL;DR: The functions of SNHG15 and miR-211-3p in breast cancer are revealed for the first time, and it is shown that there was a negative correlation between SNHg15 andMiR-212-3P expression in breast cancers patients.

TL;DR: Findings indicate that GAS5 may promote the progression of ischemic stroke through acting as a ceRNA for miR-137 to mediate the Notch1 signaling pathway, which contributes to an extensive understanding of isChemic stroke and may provide novel therapeutic options for this disease.

TL;DR: It is demonstrated that circRNA_0084043 may act as the sponge of miR-153-3p to up-regulate Snail expression, and consequently function as an oncogene in melanoma.

TL;DR: Co-transplantation of ADSC-Exos can effectively promote the survival of graft, neovascularization and attenuated inflammation in the fat grafts.

TL;DR: A novel signaling pathway of circ-ITCH/miR-22-3p/CBL/β-catenin involved in PTC development and progression is revealed, which suppresses PTC cell proliferation and invasion and promotes apoptosis in vitro.

TL;DR: SNHG12 might serve as a valuable biomarker and prognosis factor in osteosarcoma patients and the SNHG 12/miR-195-5p/Notch2-Notch signaling pathway axis might become a novel therapeutic for osteosARcoma.

TL;DR: ADSC-exos can enhance skin flap survival, promote neovascularization and alleviate the inflammation reaction and apoptosis in the skin flap after I/R injury.

TL;DR: It is shown that the expression level of hsa_circ_0001649 was down-regulated in CRC and could use it as a new biomarker for specific and sensitive inspection of CRC.

TL;DR: It is demonstrated that circMAN2B2 acts as an oncogenic role in lung cancer through promoting FOXK1 expression by sponging miR-1275, and restoration ofFOXK1 could rescue circMAN 2B2 knockdown-induced repression of cell proliferation and invasion.

TL;DR: TGF-β plays a vital role in TNBC epirubicin-resistance through regulating stemness, EMT and apoptosis, and taken together, suggests that the drug resistance of cancer may also be affected.

TL;DR: It is suggested that circ_0009910 acted as a sponge of miR-449a and upregulated miR -449a functional target IL6R, thereby contributed to carcinogenesis of OS.

TL;DR: It is shown that circ_0026344 expression was downregulated in CRC tissues compared to adjacent normal tissues, and the level of circ_026344 was inversely correlated with CRC advance and lymphoid node metastasis and regulatory signaling was implicated in CRC progression.

TL;DR: It is found that circ_0016760 was enhanced in NSCLC tissues and cells and the upregulation of circ_ 0016760 is associated with advanced TNM stages, lymph node metastasis and adverse prognosis in NS CLC patients.