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Balachandran S Vinod
Researcher at Rajiv Gandhi Centre for Biotechnology
Publications - 9
Citations - 423
Balachandran S Vinod is an academic researcher from Rajiv Gandhi Centre for Biotechnology. The author has contributed to research in topics: Cancer & Thymidylate synthase. The author has an hindex of 6, co-authored 8 publications receiving 327 citations.
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Phytochemicals As Chemosensitizers: From Molecular Mechanism to Clinical Significance
TL;DR: An overview of the clinical relevance of chemosensitization is provided, giving special reference to the phenolic phytochemicals, curcumin, genistein, epigallocatechin gallate, quercetin, emodin, and resveratrol, which are potential candidates due to their ability to regulate multiple survival pathways without inducing toxicity.
Journal ArticleDOI
Mechanistic evaluation of the signaling events regulating curcumin-mediated chemosensitization of breast cancer cells to 5-fluorouracil.
Balachandran S Vinod,Jayesh Antony,Haritha H. Nair,Vineshkumar Thidil Puliyappadamba,Minakshi Saikia,Sai Shyam Narayanan,A Bevin,R John Anto +7 more
TL;DR: It is found that 10 μM 5-FU and 10”μM curcumin induces a synergistic cytotoxic effect in different breast cancer cells, independent of their receptor status, through the enhancement of apoptosis.
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Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2-Akt axis.
Balachandran S Vinod,Haritha H. Nair,Vinod Vijayakurup,A Shabna,Safdar Hussain Shah,A Krishna,Kavya S. Pillai,Sanu Thankachan,Ruby John Anto +8 more
TL;DR: The role of Her-2–Akt signaling axis is established in regulating the synergistic effect of docetaxel and resveratrol in breast cancer cells overexpressing HER-2, and might help to overcome therapeutic resistance during breast cancer therapy.
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Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent.
Vineshkumar Thidil Puliyappadamba,Vino T. Cheriyan,Arun Kumar T. Thulasidasan,Smitha V. Bava,Balachandran S Vinod,Priya R. Prabhu,Ranji Varghese,Arathy Bevin,Shalini Venugopal,Ruby John Anto +9 more
TL;DR: The present study reveals a detrimental role of nicotine especially in lung cancer patients with impaired p53 status and identifies curcumin as a potential chemopreventive.
Journal ArticleDOI
ATF2 maintains a subset of neural progenitors through CBF1/Notch independent Hes-1 expression and synergistically activates the expression of Hes-1 in Notch-dependent neural progenitors.
Rajendran Sanalkumar,Chandrasekharan Lalitha Indulekha,Thulasi Sheela Divya,Mundackal Sivaraman Divya,Ruby John Anto,Balachandran S Vinod,Sasidharan Vidyanand,Balusamy Jagatha,Shalini Venugopal,Jackson James +9 more
TL;DR: In this paper, it was shown that Hes-1 expression can be regulated by alternate signaling pathways independent of canonical Notch/CBF1 interaction, without the requirement of interaction from neighboring cells during development.