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Baltazar Zavala
Researcher at St. Joseph's Hospital and Medical Center
Publications - 15
Citations - 1919
Baltazar Zavala is an academic researcher from St. Joseph's Hospital and Medical Center. The author has contributed to research in topics: Subthalamic nucleus & Deep brain stimulation. The author has an hindex of 12, co-authored 14 publications receiving 1564 citations. Previous affiliations of Baltazar Zavala include National Institutes of Health & John Radcliffe Hospital.
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Journal ArticleDOI
Adaptive deep brain stimulation in advanced Parkinson disease
Simon Little,A Pogosyan,Spencer Neal,Baltazar Zavala,Ludvic Zrinzo,Marwan Hariz,Thomas Foltynie,Patricia Limousin,Keyoumars Ashkan,James J. FitzGerald,Alexander L. Green,Tipu Z. Aziz,Peter Brown +12 more
TL;DR: This work uses a BCI to interpret pathological brain activity in patients with advanced Parkinson disease and to use this feedback to control when therapeutic deep brain stimulation (DBS) is delivered to improve on both the efficacy and efficiency of conventional continuous DBS.
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Activity-Dependent Long-Term Depression of Electrical Synapses
TL;DR: Modification of electrical synapses resulting from activity in coupled neurons is likely to be a widespread and powerful mechanism for dynamic reorganization of electrically coupled neuronal networks.
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Midline Frontal Cortex Low-Frequency Activity Drives Subthalamic Nucleus Oscillations during Conflict
Baltazar Zavala,Huiling Tan,Simon Little,Keyoumars Ashkan,Marwan Hariz,Thomas Foltynie,Ludvic Zrinzo,Kareem A. Zaghloul,Peter Brown +8 more
TL;DR: The cortico-subcortical circuit enabling successful choices to be made under conditions of conflict is established and support for the hypothesis that the brain uses frequency-specific channels of communication to convey behaviorally relevant information is provided.
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Neural Correlates of Decision Thresholds in the Human Subthalamic Nucleus
TL;DR: It is shown that trial-by-trial variations in STN low-frequency oscillatory activity predict adjustments of decision thresholds before subjects make a response, which might explain why deep-brain stimulation of the STN can impair subjects' ability to slow down responses and can induce impulsive suboptimal decisions.
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Subthalamic Nucleus Local Field Potential Activity during the Eriksen Flanker Task Reveals a Novel Role for Theta Phase during Conflict Monitoring
Baltazar Zavala,John-Stuart Brittain,Ned Jenkinson,Keyoumars Ashkan,Thomas Foltynie,Patricia Limousin,Ludvic Zrinzo,Alexander L. Green,Tipu Z. Aziz,Kareem A. Zaghloul,Peter Brown +10 more
TL;DR: Recordings from deep brain stimulation electrodes implanted bilaterally in the STN of 13 human subjects with Parkinson's disease while they performed a flanker task suggest disruption of STN theta phase alignment may help operationalize the hold-your-horses role of the nucleus, whereas later increases in the amplitude of theta oscillations may help overcome this function.