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Barbara A. Smith
Researcher at University of York
Publications - 28
Citations - 2375
Barbara A. Smith is an academic researcher from University of York. The author has contributed to research in topics: Urothelium & Reverse transcriptase. The author has an hindex of 21, co-authored 28 publications receiving 2286 citations. Previous affiliations of Barbara A. Smith include St James's University Hospital & Hull York Medical School.
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Journal ArticleDOI
Detection of melanoma cells in peripheral blood by means of reverse transcriptase and polymerase chain reaction.
TL;DR: The method was highly sensitive and could detect a single melanoma cell from a cell line in 2 ml normal blood, and could prove useful in the diagnosis of primary or metastatic cancers, in assessing prognosis, and in detecting residual disease after treatment.
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Detection of epithelial cancer cells in peripheral blood by reverse transcriptase-polymerase chain reaction.
TL;DR: It is found that reverse transcriptase (RT)-PRC for tissue-specific gene expression is a useful technique for identifying small numbers of circulating cells in melanoma and neuroblastoma patients and suggests a role for RT-PCR in the detection of colon carcinoma metastasis in blood and bone marrow.
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Uroplakin gene expression in normal human tissues and locally advanced bladder cancer
Jonathon D. Olsburgh,Patricia Harnden,Robert J. Weeks,Barbara A. Smith,Adrian D. Joyce,Geoffrey Hall,Richard Poulsom,Peter Selby,Jennifer Southgate +8 more
TL;DR: Results confirm that in human tissues the expression of UPIa and UPII genes is highly specific to urothelium and suggest that the tight differentiation‐restricted expression of uroplakin genes in normal urothalium is lost following malignant transformation.
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Genomic Confirmation of Hybridisation and Recent Inbreeding in a Vector-Isolated Leishmania Population
Matthew B. Rogers,Tim Downing,Barbara A. Smith,Hideo Imamura,Mandy Sanders,Milena Svobodová,Petr Volf,Matthew Berriman,James Cotton,Deborah F. Smith +9 more
TL;DR: Patterns of linkage disequilibrium indicate that this population reproduced primarily clonally following the original hybridisation event, but that some recombination also occurred, the first quantitative estimate of these events during the Leishmania life cycle.
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Uroplakin gene expression by normal and neoplastic human urothelium.
E. Dawn Lobban,Barbara A. Smith,Geoffrey Hall,Patricia Harnden,Paul Roberts,Peter Selby,Ludwik K. Trejdosiewicz,Jennifer Southgate +7 more
TL;DR: Compared with the three differentiation-regulated uroplakins, UPIb may have an alternative role in urothelial cell/tissue processes and correlated with patterns of uROplakin expression in tumors.