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Barbara E. Murray
Researcher at University of Texas Health Science Center at Houston
Publications - 21
Citations - 3699
Barbara E. Murray is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Enterococcus faecalis & Virulence. The author has an hindex of 19, co-authored 21 publications receiving 3528 citations. Previous affiliations of Barbara E. Murray include Mayo Clinic & Emerging Pathogens Institute.
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Journal ArticleDOI
A simple model host for identifying Gram-positive virulence factors
Danielle A. Garsin,Costi D. Sifri,Eleftherios Mylonakis,Xiang Qin,Kavindra V. Singh,Barbara E. Murray,Stephen B. Calderwood,Frederick M. Ausubel +7 more
TL;DR: The use of the nematode Caenorhabditis elegans is demonstrated as a facile and inexpensive model host for several Gram-positive human bacterial pathogens and an E. faecalis virulence factor, ScrB, which is relevant to mammalian pathogenesis is exploited.
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Effects of Enterococcus faecalis fsr genes on production of gelatinase and a serine protease and virulence
TL;DR: Results suggest that sprEand agr-like genes contribute to the virulence of E. faecalis OG1RF in this model, and that both gelE and fsr are necessary for gelatinase production.
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Influence of origin of isolates, especially endocarditis isolates, and various genes on biofilm formation by Enterococcus faecalis
TL;DR: Mutants disrupted in dltA, efaA, ace, lsa, and six two-component regulatory systems were largely unaltered, while disruptions in epa, atn, gelE, and fsr resulted in fewer attached bacteria, as determined using phase-contrast microscopy, and less biofilm.
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Diversity among multidrug-resistant enterococci.
TL;DR: Enterococci are associated with both community- and hospital-acquired infections and resistance to antimicrobial drugs, and enterococcal hardiness likely adds to resistance by facilitating survival in the environment and enhancing potential spread from person to person.
Journal ArticleDOI
Large scale variation in Enterococcus faecalis illustrated by the genome analysis of strain OG1RF
Agathe Bourgogne,Danielle A. Garsin,Xiang Qin,Kavindra V. Singh,Jouko Sillanpää,Shailaja Yerrapragada,Yan Ding,Shannon Dugan-Rocha,Christian J. Buhay,Hua Shen,Guan Chen,Gabrielle Williams,Donna M. Muzny,Arash Maadani,Kristina A. Fox,Jason Gioia,Lei Chen,Yue Shang,Cesar A. Arias,Sreedhar R. Nallapareddy,Meng Zhao,Vittal P. Prakash,Shahreen Chowdhury,Huaiyang Jiang,Richard A. Gibbs,Barbara E. Murray,Sarah K. Highlander,George M. Weinstock +27 more
TL;DR: OG1RF's effects in experimental models suggest that mediators of virulence may be diverse between different E. faecalis strains and that virulence is not dependent on the presence of mobile genetic elements.