Barbara Gisabella

TL;DR: It is demonstrated that GABA dysfunction increases long-term potentiation through activation of the cholinergic system, offering a new mechanism for pharmacological strategies of this disorder.

TL;DR: These studies provide a new link between stress, a novel type of metabolic resistance, and vulnerability to excessive fear memory formation and reveal that ghrelin can regulate negative emotionality in unstressed animals without altering appetite.

TL;DR: In this paper, the role of serotonin in subsequent fear learning was investigated using a rodent model of stress-based susceptibility to PTSD, and the results reveal that predictions from classical associative learning models do not always hold for stressed animals and suggest that 5-HT2CR blockade may represent a promising therapeutic target for psychiatric disorders characterized by excessive fear responses such as that observed in PTSD.

TL;DR: It is concluded that the preconditioning inhibition of LTP induction is a complex process which involves activation of NMDAR, group I and group II mGluR, and intracellular cascades activating PKC and p38 MAP kinase.

TL;DR: It is suggested that rhythmic modification of PNNs may contribute to memory consolidation during sleep, as well as in a circadian manner in the rodent brain, and this is disrupted by sleep deprivation.