The R package mice imputes incomplete multivariate data by chained equations. The software mice 1.0 appeared in the year 2000 as an S-PLUS library, and in 2001 as an R package. mice 1.0 introduced predictor selection, passive imputation and automatic pooling. This article documents mice, which extends the functionality of mice 1.0 in several ways. In mice, the analysis of imputed data is made completely general, whereas the range of models under which pooling works is substantially extended. mice adds new functionality for imputing multilevel data, automatic predictor selection, data handling, post-processing imputed values, specialized pooling routines, model selection tools, and diagnostic graphs. Imputation of categorical data is improved in order to bypass problems caused by perfect prediction. Special attention is paid to transformations, sum scores, indices and interactions using passive imputation, and to the proper setup of the predictor matrix. mice can be downloaded from the Comprehensive R Archive Network. This article provides a hands-on, stepwise approach to solve applied incomplete data problems.

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mice: Multivariate Imputation by Chained Equations in R

This article gives a comprehensive introduction into one of the main branches of evolutionary computation – the evolution strategies (ES) the history of which dates back to the 1960s in Germany Starting from a survey of history the philosophical background is explained in order to make understandable why ES are realized in the way they are Basic ES algorithms and design principles for variation and selection operators as well as theoretical issues are presented, and future branches of ES research are discussed

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Evolution strategies –A comprehensive introduction

Basics Introduction The problem of missing data Concepts of MCAR, MAR and MNAR Simple solutions that do not (always) work Multiple imputation in a nutshell Goal of the book What the book does not cover Structure of the book Exercises Multiple imputation Historic overview Incomplete data concepts Why and when multiple imputation works Statistical intervals and tests Evaluation criteria When to use multiple imputation How many imputations? Exercises Univariate missing data How to generate multiple imputations Imputation under the normal linear normal Imputation under non-normal distributions Predictive mean matching Categorical data Other data types Classification and regression trees Multilevel data Non-ignorable methods Exercises Multivariate missing data Missing data pattern Issues in multivariate imputation Monotone data imputation Joint Modeling Fully Conditional Specification FCS and JM Conclusion Exercises Imputation in practice Overview of modeling choices Ignorable or non-ignorable? Model form and predictors Derived variables Algorithmic options Diagnostics Conclusion Exercises Analysis of imputed data What to do with the imputed data? Parameter pooling Statistical tests for multiple imputation Stepwise model selection Conclusion Exercises Case studies Measurement issues Too many columns Sensitivity analysis Correct prevalence estimates from self-reported data Enhancing comparability Exercises Selection issues Correcting for selective drop-out Correcting for non-response Exercises Longitudinal data Long and wide format SE Fireworks Disaster Study Time raster imputation Conclusion Exercises Extensions Conclusion Some dangers, some do's and some don'ts Reporting Other applications Future developments Exercises Appendices: Software R S-Plus Stata SAS SPSS Other software References Author Index Subject Index

Flexible Imputation of Missing Data

The goal of multiple imputation is to provide valid inferences for statistical estimates from incomplete data. To achieve that goal, imputed values should preserve the structure in the data, as well as the uncertainty about this structure, and include any knowledge about the process that generated the missing data. Two approaches for imputing multivariate data exist: joint modeling (JM) and fully conditional specification (FCS). JM is based on parametric statistical theory, and leads to imputation procedures whose statistical properties are known. JM is theoretically sound, but the joint model may lack flexibility needed to represent typical data features, potentially leading to bias. FCS is a semi-parametric and flexible alternative that specifies the multivariate model by a series of conditional models, one for each incomplete variable. FCS provides tremendous flexibility and is easy to apply, but its statistical properties are difficult to establish. Simulation work shows that FCS behaves very well in ...

Multiple imputation of discrete and continuous data by fully conditional specification

SUMMARY The paper extends earlier work on the so-called skew-normal distribution, a family of distributions including the normal, but with an extra parameter to regulate skewness. The present work introduces a multivariate parametric family such that the marginal densities are scalar skew-normal, and studies its properties, with special emphasis on the bivariate case.

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The multivariate skew-normal distribution

This chapter discusses via an interview with Jerzy Filus about his career from his early years in Poland all the way up to today, we will unfold and explore the genesis and development of multivariate pseudonormal distributions, parameter dependence, and finally stochastic dependence in general. As a kind of fusion of the two approaches, the common paper Filus, Filus, and Arnold demonstrated a method of extension of the bivariate normal density where only six parameters were needed; in the Arnold et al. approach, eight parameters were needed as a minimum. In Filus and Filus, the authors gave a reliability motivation for pseudonormal distributions using the parameter dependence paradigm. In this area, Jerzy Filus and coauthors have made substantial recent developments on this topic and propose an interesting new model. In Filus, Filus and Stehlik, a statistical study was conducted related to bivariate pseudoexponential distribution via its survival function, which allows to model other multiple failures.

On Parameter Dependence and Related Topics: The Impact of Jerzy Filus from Genesis to Recent Developments

Conditional specification of statistical models: Classical models, new developments and challenges

In this paper, we discuss approaches to the determination of a bivariate distribution by specifying the two conditional density functions, the two conditional survival functions, the two hazard components and the two conditional hazard functions of one variable given the value of the other. In addition, the case in which one considers determination of the joint distribution by specifying the conditional distribution of each variable given that the other variable is bounded below is discussed. Examples are provided in each case.

Alternative approaches to conditional specification of bivariate distributions

A bivariate conditionally specified distribution is one in which the dependence relationship between the two random variables is accomplished by defining the distribution of one of the random varia...

On bivariate pseudo-exponential distributions

In the competing risks/multiple decrement model, the joint distribution is often not identifiable given only the observed time of failure and the cause of failure. The traditional approach is consequently to assume a parametric model. In this paper we shall not do this, but rather assume a Bayesian stance, take a Dirichlet process as a prior distribution, and then calculate the posterior distribution given the data. In this paper we show that in dimensions ⩾ 2, the posterior mean yields an inconsistent estimator of the joint probability law, contrary to the common assumption that the prior law ‘washes out’ with large samples. For single decrement mortality tables however, the non-parametric Bayesian method allows a flexible method for adjusting a standard mortality table to reflect mortality experience, or covariate information.

Barry C. Arnold

Papers

On Parameter Dependence and Related Topics: The Impact of Jerzy Filus from Genesis to Recent Developments

Conditional specification of statistical models: Classical models, new developments and challenges

Alternative approaches to conditional specification of bivariate distributions

On bivariate pseudo-exponential distributions

On the inconsistency of Bayesian non-parametric estimators in competing risks/multiple decrement models